Comment · Tue, December 17, 2024 · ND Owner
Will taking GABA agonists for sleep downregulate it long term? Advice for the sleep stack supplements please!
Original post in this thread
Obviously1138 · 9 points
I have severe ME/CFS and my insomnia is not something I can cure with lifestlye changes. I rarely use screens and have a good sleep hygiene.
As my illness progressed I started to sleep less, with my problem mostly being waking up during the night. Sometimes after 2 to 4 hours and not being able to fall asleep after.
With supplements, I am able to get decent 6-7 hours meaning I can fall asleep easier when I wake up. I thought about low dose antidepressants because of my chronic condition but my SIBO/gut dysbiosis makes me not a good candidate.
I try to cycle by changing to a different supplement every 4-5 days. Have been wanting to find a bigger rotating stack cause most of these are ineffective if used more than 3 days a month.
But upon reading have found that most of these are either GABA agonist or can in some way downregulate GABA so now I am scared if I am doing that. What are the chances?
Raw-dogging sleep for 4 months worsened my state permanently so that's not an option. I would get 3h of sleep a night.
My stack/schedule is:
- taurine 5 days 1-2g
- L-theanine 4days 250-500 mg
- zopiclone
- glycine 5 days 1-2g
- 5htp 4 days 100-150mmg
- zopiclone
and repeat
Sometimes…
What they were answering
Chargers95 · 1 points
Any chance of an ND hops extract? I thought one existed quite a while back
u/MisterYouAreSoDumb · ND Owner
We sold Perluxan before, but that was an alpha acid extract made for pain, not calming/sleep. We have been working on other hops extracts, though. It's just tough to find one that is standardized the way we want. However, I went on a bit of a year end spending spree the past few weeks. We are building out an extraction lab at our facility, with all this badass Buchi equipment.
We got this supercritical CO2 prep system with mass spec detector, which will allow us to identify and isolate active compounds, and make reference standards much quicker.
https://www.buchi.com/en/products/instruments/sepiatec-sfc-systems
Then we got the E-800 universal extractor, so we can try a bunch of different extraction techniques on raw materials, to see what works best.
https://www.buchi.com/en/products/instruments/universalextractor-e-800
Then we got this parallel evaporator to remove the solvents from the extracts we make.
https://www.buchi.com/en/products/instruments/syncoreplus
Then we got this spray dryer to turn the extracts back into powders.
https://www.buchi.com/en/products/instruments/spray-dryer-s300
... with an inert loop for using organic solvents.
https://www.buchi.com/en/products/instruments/inert-loop-s395
So we will have a full R&D extraction setup now!