Comment · Thu, December 12, 2024 · ND Owner
Will taking GABA agonists for sleep downregulate it long term? Advice for the sleep stack supplements please!
Original post in this thread
Obviously1138 · 9 points
I have severe ME/CFS and my insomnia is not something I can cure with lifestlye changes. I rarely use screens and have a good sleep hygiene.
As my illness progressed I started to sleep less, with my problem mostly being waking up during the night. Sometimes after 2 to 4 hours and not being able to fall asleep after.
With supplements, I am able to get decent 6-7 hours meaning I can fall asleep easier when I wake up. I thought about low dose antidepressants because of my chronic condition but my SIBO/gut dysbiosis makes me not a good candidate.
I try to cycle by changing to a different supplement every 4-5 days. Have been wanting to find a bigger rotating stack cause most of these are ineffective if used more than 3 days a month.
But upon reading have found that most of these are either GABA agonist or can in some way downregulate GABA so now I am scared if I am doing that. What are the chances?
Raw-dogging sleep for 4 months worsened my state permanently so that's not an option. I would get 3h of sleep a night.
My stack/schedule is:
- taurine 5 days 1-2g
- L-theanine 4days 250-500 mg
- zopiclone
- glycine 5 days 1-2g
- 5htp 4 days 100-150mmg
- zopiclone
and repeat
Sometimes…
What they were answering
MuscaMurum · 1 points
Glad you found a reliable reference standard. I know you've been working on this a while and I can't wait to try yours out. I started taking the Swanson's product at the same time I began a Hops extract, so I couldn't chalk up my better sleep to Swanson's E Cava for sure. I assumed that if Swanson's didn't have actual E Cava, that they at least had some sort of brown seaweed that contained phlorotannins. Looks like it's a wash. I wonder what they have instead.
u/MisterYouAreSoDumb · ND Owner
Hops absolutely improves sleep, through the humulone in them. You might have gotten a high humulone extract.