Comment · Wed, December 11, 2024 · ND Owner
Will taking GABA agonists for sleep downregulate it long term? Advice for the sleep stack supplements please!
Original post in this thread
Obviously1138 · 9 points
I have severe ME/CFS and my insomnia is not something I can cure with lifestlye changes. I rarely use screens and have a good sleep hygiene.
As my illness progressed I started to sleep less, with my problem mostly being waking up during the night. Sometimes after 2 to 4 hours and not being able to fall asleep after.
With supplements, I am able to get decent 6-7 hours meaning I can fall asleep easier when I wake up. I thought about low dose antidepressants because of my chronic condition but my SIBO/gut dysbiosis makes me not a good candidate.
I try to cycle by changing to a different supplement every 4-5 days. Have been wanting to find a bigger rotating stack cause most of these are ineffective if used more than 3 days a month.
But upon reading have found that most of these are either GABA agonist or can in some way downregulate GABA so now I am scared if I am doing that. What are the chances?
Raw-dogging sleep for 4 months worsened my state permanently so that's not an option. I would get 3h of sleep a night.
My stack/schedule is:
- taurine 5 days 1-2g
- L-theanine 4days 250-500 mg
- zopiclone
- glycine 5 days 1-2g
- 5htp 4 days 100-150mmg
- zopiclone
and repeat
Sometimes…
What they were answering
MuscaMurum · 2 points
Can you tell if it contain phlorotannins?
u/MisterYouAreSoDumb · ND Owner
Here is the UPLC assay for dieckol of Swanson's product.
You can see there is nothing else in there eluting as a peak. Phlorotannins have chromophores, so we would likely see them in there as peaks if they were there. Obviously we would have to do some validation work on the method to know for absolute certainty, but it doesn't look great.
Here is the HPTLC plate of the Swanson product.
Lanes 1-5 is our validated Ecklonia cava BRM at increasing concentrations. We literally sourced raw Ecklonia cava off an island in Korea, had a local university there confirm it via botany, then did DNA sequencing to ensure it was real. We are the only ones out there with a real validated BRM for Ecklonia cava. Lanes 6-10 is the Swanson product. You can see there is not a whole lot in there at all. We have been working on this for years, and went through a lot of shit to be able to make these standards and build these methods.
Here is our Ecklonia cava that we will release soon.
Lanes 1-3 are the BRM, and lanes 4-6 are our product.