Pomegranate seed oil request, high in non-feminizing 17-Alpha-Estradiol which boosts lifespan in male mice

I totally understand your perspective. Part of that stems from our poor website layout and marketing. It's confusing for people because we really don't hand hold anyone. We give people access to a lot of different things, but we force them to figure out what works best for them. That's kind of the cornerstone of the biohacking/nootropics community. Everyone responds so differently to things that one product doesn't fit all. To find what works best for your individual body/brain chemistry requires trial and error. To do that, you need access to different versions of the "same" thing. For newcomers that can be extremely frustrating, as knowing where to start or what to try can be tough to determine. I absolutely admit we are about as friendly to newbies as dropping them onto NCBI and saying: "Good luck! Come back when you have read all the studies!" I've known that shortcoming for a while, and we are in the process of a total site redesign that includes a complete revamp of our entire process. It's not just a new theme for Bigcommerce that will be a shiny shell on the old frame. We are completely changing our process from the ground up to coincide with the new site.

A big part of that is simplification and standardization. We've been around 11 years now. It's grown organically over that time. That type of growth leads to disjointed messaging at lot of the time, if you don't take a step back and refocus. Some of our product descriptions, blogs, or buying guides were written many years ago, and the info on there doesn't jive with the info from products more recently released. Things like suggested stacks or combos might not make total sense because we haven't gone back to look at many of the older products. That's changing with this redesign. Moreover, we are massively simplifying how we describe products and talk about effects. Every product is going to to have a primary use, and then a maximum of four effect tags. Limiting the effects we talk about will help prevent confusion, and set products apart from each other. Also, using simple messaging for those effects will help newcomers understand what a product is meant for. We are eliminating the massive amount of categories on the site, and simplifying products down to a more focused messaging for customers. Each product will have four bullet points that will tie back into the effect tags. Every product page will have a use snapshot at the top, which will tell you what the dose is, when to take it, if you take with or without food, dose frequency, and how long it will take for you to notice the full effects. This is going to help customers understand how to take products, what effects they should expect, and how many days of dosing they should wait before assessing those effects. We have also built out a central database for all this data on every product, and everyone in the organization will have access to it to ensure that our messaging is always consistent. This means that if marketing wants to make an infographic or an ad, or customer support gets an email asking about a product, their responses will all be consistent with each other. Moreover, this backend system we have developed is giving us the ability to have one of the more exiting parts of our redesign: our medical review board. A team of medical doctors, PhD researchers, and herbalists is going to be reviewing all our content and signing off on the validity of it. A big part of the backend system we have developed is the ability to attach research citations to every claim. Our medical review board will then use these citations to determine if our data is scientifically sound and substantiated. This is going to not only give customers confidence in what they are reading on our site, but is going to force us to have a lot more formalized substantiation of anything we say on a product. To top it all off, for newcomers that need a bit more hand-holding, we are going to have a questionnaire on the homepage that will help direct people to the specific products that might suit them. It will ask questions about the person, if they are male or female, if they workout, their diet, what effects they are looking for, and what all they are looking to achieve, and it will give them suggestions based on their profile. This will help simplify our offerings to people just starting out. We want to make our site and our product offerings more approachable for the average person, while still giving meaningful information to all the advanced people that already buy from us. I am excited!

Also, a lot of the newer products we have been releasing have been supercritical CO2 extracts of things we already sell. We have been playing around with that extraction type to see how it can pull different actives over than the more traditional water/ethanol extractions. It's a really cool extraction type, and we can get some interesting effects by using it. This is especially true for botanicals that have volatile organics that get lost or destroyed in the other extractions. You mention Boswellia. The phytosome one was actually a customer request. We had a few customers that said they really had good effects from it, and asked if we could carry it, so we decided to. I was already messing around with the supercritical CO2 extract, and I liked the effects from the volatiles from that, so we brought that one out as well. That was more for me personally, because I wanted to have access to it. The new Cistanche extracts are also because of customer requests. We released CistaMAX, but some customers in the EU asked if we could just release the supercritical CO2 Cistanche by itself, because DHEA is a problem with their customs. The same goes for the Dioscorea nipponica. It's in Tribugen, but customers asked if we could release it standalone so they could try it by itself. A lot of these are so customers have the ability to build their own stacks instead of using the Natrium ones. The more advanced customers want to tailor their regimen exactly, so we give that option. I think it's a pretty cool thing we do. You can buy our premade Natrium stacks, or you can build your own using the same ingredients. It does make it confusing for newbies, but it is nice for the more advanced customers. The curcumins are more to offer things people are already looking for. Some people search for Longvida or Meriva, so offering both allows us to reach more people. The Curowhite was more because I thought the chemistry was cool! Hydrogenating the curcuminoids to not only remove the color, but improve their pharmacokinetics, I thought was a novel way to go about it. It is a bit confusing with all the offerings, but sometimes we do things just for cool science reasons.

Ethyl Pyruvate seems like an interesting anti-inflammatory. However, I think there is an issue with translating the results to humans.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742706/

There is one critical issue that has to be addressed when thinking about translating the application of EP from animal studies to clinical trials—the in vivo activation site of EP. When pyruvate interacts with hydrogen peroxide it forms an unstable intermediate 2-hydroperoxy-2-hydroxypropanoate, which then goes through rearrangement to produce acetate, carbon dioxide, and water. Its rearrangement is initiated by the release of carbon dioxide from the carboxyl group. In EP, the ester formation blocks the pyruvate carboxyl group, thus disabling the rearrangement to form the products listed above. Carboxylesterase is an enzyme that converts EP to pyruvate in vivo and it is uniformly present in mammalian cells. However, not all mammals have this enzyme in the blood plasma. Specifically, it is present in the blood plasma of rodents, but not humans [114, 115]. Therefore, when applied systemically in rodents, EP can be activated in the blood plasma to achieve sufficient extracellular concentration so that the derived pyruvate can reduce extracellular H2O2. However, in humans, EP can be activated only in the intracellular environment. The generated pyruvate will thus have little impact on hydrogen peroxide levels because pyruvate is rapidly metabolized. This can be one explanation for the discordance between the results obtained in animal and human studies [116].

I think the main issue with Ursolic Acid was cost. We were not able to get the costs down to a reasonable level, so we shelved it. I will circle back on it, though. It does seem like a cool compound.