Comment · Tue, May 21, 2024 · ND Owner
Pomegranate seed oil request, high in non-feminizing 17-Alpha-Estradiol which boosts lifespan in male mice
Original post in this thread
Medium-Error-1275 · 16 points
I haven't read this study but it might help with cognition as well:
>Methods:
>
>Eighty people with the diagnosis of MCI were randomized forty to take 5 drops of PSO and follow the Mediterranean Diet (MeDi) and forty just followed MeDi. All were examined with an extensive neuropsychological assessment before and after one year of treatment.
Results:
>
>The results showed that the participants who took the PSO had statistically significantly better global cognition (p = 0.004), verbal episodic memory (p = 0.009), and processing and executive functions (p < 0.001) in contrast with the participants who did not take it.
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad231100
What they were answering
whereismyface_ig · 16 points
imagine ND actually looking into product requests instead of working on their 20th variation of cistanche / red reishi / berberine / boswellia / rhodiola / curcumin / NAD / etc
u/MisterYouAreSoDumb · ND Owner
You want another glutathione? I'm sure I could find another functional group to acetylate. Just say the word, buster! How about another ashwagandha? Maybe a pre-digested acid hydrolyed glycowithanolide extract? It'll blow your dick off! I'll release ashwagandhas till the end of your natural born life, if you don't watch your step!
In all seriousness, we have to make products that people will actually buy. The cistanche, tongkat, and tribulus products sell significantly more than the others. Consumers speak with their wallets, and we need to keep the lights on. Our landlord doubled our rent. Overhead is through the roof. Every single one of the manufacturers of the equipment in our lab has jumped pricing for maintenance or replacement parts. Then wages have shot up for skilled workers, who are all feeling the pinch of inflation. Just keeping the company going is a challenge with all the increased costs. If we release products that don't move volume, we go under. It's not that we don't look into the requests that people make here. We really do. However, it's a lot more complex to release really novel things with the level we go into lab testing. It takes us many years for some things. I've dumped hundreds of thousands of dollars into products that have not yet seen the light of day. Fuck, the electrolyte is a pain in the ass! You know how complex doing a 12 ingredient stack is with our lab testing we do?!? If one of the ingredients has lab issues, it holds the whole thing up. That's what's taking so long with our electrolyte. Ecklonia cava? Fuck me, that's been a nighmare! There's no botanical reference materials, and literally nobody knows anything about how to identify it. We worked with multiple botanists in the US, and none of them can help. We had to go to Korea, and build out a DNA profile of the plant, then make our own BRMs for it. Then we had to develop a novel extraction for it, and create a standardization for it higher than anything else seen on the planet. I sure as shit hope people like it when it comes out, or the past 5 years has been a total waste of time! At least I know people will buy cistanche and tongkat. I could drop $200,000 making the best Ecklonia cava on the planet, and it is still a gamble if it is actually going to sell. The current stuff on the market is fake, so I can't go off of people's anecdotes. They're buying a totally different plant right now thinking it is Ecklonia cava. What happens when they buy our real version and don't like it as much? Fuck, I hope that doesn't happen, but who knows until we release it. People can say they want us to release certain things all the time, but if nobody really buys them, then we get screwed. It happens more than you imagine.
That being said, pomegranate seed extract has always been an interesting one for me regarding immune function. The 17-Alpha-Estradiol mechanism is another interesting one. However, it doesn't seem the results are totally conclusive.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299991/
https://e-fsbh.org/DOIx.php?id=10.52361/fsbh.2021.1.e29
17-Alpha-Estradiol is weaker than estradiol, but it displaces it from the receptor. This means that it actually antagonizes estrogen. Also, it seems to inhibit aromatase. This will lower estrogen further. That seems to be the mechanism here. It lowers estradiol, but then replaces it with 17-Alpha-Estradiol, which activates the alpha receptor, but to a lower degree than endogenous estrogen.
https://www.rapamycin.news/t/17-alpha-estradiol-another-top-anti-aging-drug/92/143?page=6
Icariin from horny goat weed also extends lifespan, binds to the alpha estradiol receptor, and stimulates bone regeneration.
https://www.sciencedirect.com/science/article/abs/pii/S0531556515300061
https://www.aging-us.com/article/203893/text
https://www.frontiersin.org/articles/10.3389/fbioe.2022.824025/full
Icariin seems cooler than grapefruit seed extract, IMO. We carry that now. I don't see anyone talking about it, though.