Comment · Tue, May 21, 2024 · ND Owner
Pomegranate seed oil request, high in non-feminizing 17-Alpha-Estradiol which boosts lifespan in male mice
Original post in this thread
Medium-Error-1275 · 16 points
I haven't read this study but it might help with cognition as well:
>Methods:
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>Eighty people with the diagnosis of MCI were randomized forty to take 5 drops of PSO and follow the Mediterranean Diet (MeDi) and forty just followed MeDi. All were examined with an extensive neuropsychological assessment before and after one year of treatment.
Results:
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>The results showed that the participants who took the PSO had statistically significantly better global cognition (p = 0.004), verbal episodic memory (p = 0.009), and processing and executive functions (p < 0.001) in contrast with the participants who did not take it.
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad231100
What they were answering
Medium-Error-1275 · 2 points
That being said, pomegranate seed extract has always been an interesting one for me regarding immune function. The 17-Alpha-Estradiol mechanism is another interesting one. However, it doesn't seem the results are totally conclusive.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299991/
https://e-fsbh.org/DOIx.php?id=10.52361/fsbh.2021.1.e29
The second study didn't use PSO (pomegranate seed oil), instead concentrate or powder of juice.
Generally the ITP (interventions testing program) by the NIH is the gold standard for mice lifespan studies, as it tests the compound at three different sites. For 17-Alpha-Estradiol it varied a lot between test sites with a median increase of 12%.
16α-hydroxyestriol was recently tested and it increased male mice lifespan by 15%, it published 16th May this year:
https://link.springer.com/article/10.1007/s11357-024-01176-2
The ITP always accepts submissions once a year at, instructions at this link, if you want to test Icariin or some other compound:
https://www.nia.nih.gov/research/dab/interventions-testing-program-itp
u/MisterYouAreSoDumb · ND Owner
The second study didn't use PSO (pomegranate seed oil), instead concentrate or powder of juice.
Very true. They may not be directly correlated. There is a 17-alpha-estradiol standard, and it has a good chromophore, so I am sure we could build out some UPLC assay methods fairly quickly. I'd be curious to see how much is in various extracts. If we brought out a pomegranate seed oil/extract, I think we would want to standardize to that. The increase in lifespan in mice is cool, but I am very curious to see how it affect humans. For me personally, I get drops in estradiol from Tongkat Ali that I need to balance out. I wonder if replacing the estradiol with 17-alpha-estradiol could work for that?