Comment · Mon, September 11, 2023 · Nootropics Depot & Natrium Health
Is B6 toxicity actually something I need to be worried about?
Original post in this thread
Banjosolo69 · 18 points
I just started a B complex and I’m loving it but I’ve seen several people on here warn about the dangers of B6 toxicity. When I google it I only find evidence stating that only abnormally high doses will cause damage, and when you stop taking it it should go away. My current B complex contains 25mg Pyroxidine and 3.4mg Pyridoxal 5’-Phosphate. What are your personal experiences with this?
What they were answering
tallr0b · 2 points
Actually, it looks like both pyridoxamine and pyridoxine and are naturally found in food.
I cannot find a source that definitively does a breakdown of all 6 vitamers in various foods.
It seems to be one of those embarrassing mistakes that will require a reassessment of a lot of old research. Current researchers in this area are writing very little about it -- probably waiting to see how the chips fall ;(
BTW: I looked at ClinicalTrials.gov, and all of the studies involving pyridoxamine were "completed" a long time ago.
u/MisterYouAreSoDumb · Nootropics Depot & Natrium Health
This is the case for NMN and NR as well.
https://link.springer.com/article/10.1007/s13668-023-00475-y
NR has been named as the third NAD+ vitamin precursor, alongside NAM and NA [65]. One of the official methods for measuring NA content in foods is by microbiological assay. In the assessment, the food matrix is submitted to an acid or alkaline treatment at a high temperature (AOAC Method 944.13). It is known that under these conditions, NAM, NAD, and NADP are converted into NA, and the alkaline treatment releases NA eventually bound to polysaccharides, peptides, or glycopeptides. Ummarino et al. (2017) investigated whether NMN and NR would also produce NA when exposed to hot acid or alkaline extraction procedures. And indeed, NR and NMN molecules were hydrolyzed to NA and could account for the total niacin content in the milk samples analyzed [42]. Hence, this indicates that the niacin quantified by microbiological assay includes NR and NMN eventually present in the food matrix.
So NMN and NR have been a part of the "total vitamin B3" content of milk forever, but our analytical methods were just not good enough to see them. Now they are, and we are discovering NMN and NR are just vitamins like niacin. Yet the FDA is trying to claim NMN is a drug. Bullshit! Pyridoxamine being naturally in food, and the FDA saying it is a drug, is just another in a long line of BS...
https://academic.oup.com/jaoac/article-abstract/44/3/426/5731029?redirectedFrom=PDF
Paper from 1961! We have known pyridoxamine is in foods longer than mos people on this site have been alive!