Comment · Wed, August 30, 2023 · ND Owner
new research on lion's mane
Original post in this thread
Conscious-Item-1633 · 16 points
What they were answering
Hopeful_Math9790 · 4 points
Some caveats
​
It was a 6 week study on mice.
"The study evaluated the effects of a H. erinaceus ethanol extract and hericene A in six-week-old ICR male mice. On days 28-30 of the study period, the mice performed a Y-maze test and novel object test before they were sacrificed and their brains preserved for biochemical and immunohistochemistry analysis."
​
furthermore it was in addition with another substance
​
"“Mice fed with H. erinaceus crude extract and hericene A also exhibited increased neurotrophin expression and downstream signaling, resulting in significantly enhanced hippocampal memory,” they wrote. “Hericene A therefore acts through a novel pan-neurotrophic signaling pathway, leading to improved cognitive performance.”"
u/MisterYouAreSoDumb · ND Owner
Biggest caveat: these compounds are only in trace amounts in most lion's mane. NDPIH is present in roughly 0.0001%- 0.001% of the mass. Hericene A is slightly higher, at 0.003% - 0.01%. These are not meaningfully active in normal doses.