Comment · Wed, November 23, 2022 · ND Owner
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What they were answering
TheGermanGuy21 · 5 points
Out of curiosity, what are the poor reactions to MK-7? I get extreme insomnia from it, but from MK-4 as well unfortunately. At least from the brands I've tried (Thorne and NOW).
Here in germany it's common for pharmacies to sell high dosed D3, e.g. 50.000 IU, meant to be taken once a week, since D3 is fat soluble.
Do you think that is a good alternative dosing strategy? I don't trust pharmacy people telling old tales about fat soluble vitamins anymore after reading your posts lol.
Since I can only handle approximately 100mcg of K2 weekly due to insomnia, I was thinking it might be better to take the D3 weekly as well, just higher dosed? Like 35.000 IU (7d \* 5.000 IU) together with 100mcg MK-7?
Since the D3 releases Calcium and currently 6 out of 7 days a week there's no K2 for me at the same time to get the Calcium where it belongs, I'm worried about calcifying my blood vessels.
u/MisterYouAreSoDumb · ND Owner
Some people get heart palpitations, headaches, brain fog, etc. from MK-7. I think it has something to do with increasing calcium too much, causing over-activation of the NMDA receptors/calcium channels. It's not really settled in the research, though. It's mostly from many anecdotes of people online. It's clearly a side effect for a portion of people out there.
I do see many strategies for vitamin D dosing. Many times it is suggested to take a really high dose weekly/monthly instead of daily. However, they studied this and showed that daily dosing of lower amounts is more effective than weekly/monthly dosing of higher doses.
In conclusion, 98% of the participants had a baseline serum 25(OH)D lower than 50 nmol/L. Oral vitamin D3 supplementation, administered daily was more effective than weekly doses in nursing home residents, while monthly administration was the least effective, 35% still having a serum 25(OH)D < 50 nmol/l after 4 months treatment in this group. Calcium supplementation did not augment the effect of vitamin D supplementation.
I was always skeptical of the idea that you can just take massive amounts of vitamin D more infrequently, and your body would just release it as needed. We know our bodies naturally produce D in a daily cycle with the sun, so why would supplementation be vastly different? As for your K2 dosing, just do what works for your body to keep you from becoming deficient. If weekly K2 works for you, you can certainly pair that with daily D3. They don't have to be taken together.