Comment · Sat, November 19, 2022 · ND Owner
What they were answering
iAmCrimm · 9 points
How long do the effects last? & Is it better taken with or without food?
u/MisterYouAreSoDumb · ND Owner
The effects build up, so you will see the most benefits in daily dosing over a couple weeks. However, there are acute effects. I notice them for 6-8 hours. I only dose once per day, and I do that mid day. I always dose on an empty stomach.
Post · Sat, November 19, 2022 · 133 pts
Where We're Going, We Don't Need Roads
Comment · Sat, November 19, 2022 · 30 pts
I'mma let you finish... but the Tickler is the best of all time. ALL TIME, MAN!
Comment · Sat, November 19, 2022 · 19 pts
[My only regret is that I have... boneitis.](https://www.youtube.com/watch?v=4O1TbUHGN_k)
Comment · Sat, November 19, 2022 · 45 pts
I've been taking it daily for quite some time. It's really nice for mood and cognition. It pairs very well with dopaminiergic compounds, especially at double the usual dose. Sabroxy is a good one to pair it with. Also, w
Comment · Sat, November 19, 2022 · 22 pts
Depends on the demand. I can't predict that. However, we are pretty sure we should be fine on supply for the short/medium term. If it takes off better than we anticipate, we will have to jump quickly to another productio
Comment · Sat, November 19, 2022 · 19 pts
Many years of work, but it is finally here!
Comment · Sat, November 19, 2022 · 21 pts
I am hoping for sometime in January for that one!
Comment · Sat, November 19, 2022 · 16 pts
Still doing some work on multiple of the ingredients we are going to use. We have a very tentative formulation, but we are trying some novel extraction techniques to see if we can get unique compounds out of the plant. I
Comment · Sat, November 19, 2022 · 12 pts
No, and I have cycled off a few times to see if there was any rebound. It's super functional at the dose we set. Perhaps if you go higher in dose you might, though.
Comment · Sat, November 19, 2022 · 10 pts
I have combined it with pretty much everything you can think of. Nothing so far has jumped out as a clear combo to stay away from.
Comment · Sat, November 19, 2022 · 20 pts
Yes, that is part of what took so long.
Comment · Sun, November 20, 2022 · 28 pts
You are correct!
Comment · Sun, November 20, 2022 · 9 pts
Includes alcohol, but usually at least spaced a few hours apart.
Comment · Sun, November 20, 2022 · 10 pts
Do you think we would just leave dopamine out of the party?!? It needs tickles, too! Plus, activating multiple receptor systems in the right balance is what really brings the magic. I do want people to put this bacopa in
Comment · Sun, November 20, 2022 · 10 pts
100% functional. Microdosing is all about sub-threshold doses resulting in mood and cognition improvements over time. The issue is many people these days are not really microdosing. They are just low dosing, but still ov
Comment · Sun, November 20, 2022 · 11 pts
That's the big issue right now. Most people microdosing are not actually doing that. They are just low dosing, but still over threshold. It alters people expectations of effects and side effects. Real microdosing is supp
Comment · Sun, November 20, 2022 · 10 pts
We have the full video dropping this week. It was fun to shoot! We usually do a theme every year for Black Friday/Cyber Monday. This year we thought it would be cool to release our bacopa at the same time, and do a whole
Comment · Sun, November 20, 2022 · 12 pts
It's a special bacopa extract we made. It's legal everywhere, as it is a common plant sold all over the world, just done in a very specific way.
Comment · Sun, November 20, 2022 · 16 pts
Tribulus should be January.
Comment · Sun, November 20, 2022 · 12 pts
It's a patented bacopa extract that we have been working on for years. It's standardized to a compound that nobody else in the world is. I will leave that as a surprise for the release, though. The aim of this is to targ
Comment · Mon, November 21, 2022 · 16 pts
The interactions with 5-HT2A and mood/cognition are pretty complex, and are very dose-dependent. We are still learning a lot about how activation of 5-HT2A can affect downstream systems. https://biblio.vub.ac.be/vubirfi
Comment · Mon, November 21, 2022 · 6 pts
It shouldn't be, as what we have standardized to has no affinity for acetylcholinesterase. It's primarily targeting 5-HT2A and M1 muscarinic acetylcholine receptors.
Comment · Mon, November 21, 2022 · 7 pts
Yep, it is an agonist/PAM of the M1 receptor, and is slightly stimulating.
Comment · Mon, November 21, 2022 · 9 pts
Ours is a positive allosteric modulator of 5-HT2A, not a full agonist. This is a big difference. Also, it's much more complex than just activation of 5-HT2A. It's M1 ACh, BDNF, and reelin as well. Generally, down-regulat
Comment · Tue, November 22, 2022 · 3 pts
I am the same. Sabroxy works fairly well for me, but I keep it to low doses to avoid side effects. This other one I really respond well to, though. I am just like you. I respond much better to releasers than re-uptake in
Comment · Tue, November 22, 2022 · 6 pts
Yes, it is hitting multiple downstream mechanisms that affect memory.
Comment · Tue, November 22, 2022 · 5 pts
Yes, our new bacopa has more acute effects. They are also different effects than our 24%. This new one is actually a bit stimulating, so I take it in the morning or mid day.
Comment · Tue, November 22, 2022 · 8 pts
Correct. It should be less likely to cause that issue. In fact, I find it to be lightly stimulating.
Comment · Tue, November 22, 2022 · 4 pts
It doesn't appear to be in that database yet. USPTO are slow bois. I'll check with our patent attorneys to see if they know when/how long it takes them to disseminate things.
Comment · Tue, November 22, 2022 · 9 pts
Positive allosteric modulators increase the activation of a receptor without actually binding to the main site of the receptor. PAMs interact with binding sites that are distinct from the orthosteric site recognized by t
Comment · Tue, November 22, 2022 · 5 pts
I actually have. I have combined with 7,8-DHF as well. They seem to combine together very well. This one is certainly going to be going in some Natrium stacks later on.
Hey everyone, I saw a new research study today that I wanted to bring up. It highlights why my main mission over the past 10 years has been to not only advance the lab testing and quality control standards of the indust
**I'm going to copy what I wrote on another thread:** _____________________________________________________ YES! Keep your damn body temperatures down people! http://www.maps.org/publications/1998_malberg_1.pdf http:
Hey everyone, it's been a while since I have made a post in this sub. However, I saw a new research study today that I wanted to bring up. It highlights why my main mission over the past 10 years has been to not only adv
Replying to lewanay · Their top pick is Youtheory over ND: “Like Youtheory, Nootropics Depot also contains PrimaVie, but it is more expensive: A serving of Nootropics offering 250 mg of extract costs 6…
The youTheory capsules are 250mg like ours. They just tell you to take 2 for a dose. That's the dosing games brands play to trick people into thinking they are cheaper. If they wanted a dose to be 500mg, they should have
It's a massive frustration of mine with other brands. Sellers will unnecessarily spread doses over multiple capsules to increase capsule counts, to seem like a better value. This is to trick consumers into thinking they
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory