Comment · Tue, November 22, 2022 · ND Owner
What they were answering
VirtualTools_ · 7 points
Ooo. a DRA! I don't respond well to DRIs so that might work better
u/MisterYouAreSoDumb · ND Owner
I am the same. Sabroxy works fairly well for me, but I keep it to low doses to avoid side effects. This other one I really respond well to, though. I am just like you. I respond much better to releasers than re-uptake inhibitors.
Post · Sat, November 19, 2022 · 133 pts
Where We're Going, We Don't Need Roads
Comment · Sat, November 19, 2022 · 30 pts
I'mma let you finish... but the Tickler is the best of all time. ALL TIME, MAN!
Comment · Sat, November 19, 2022 · 19 pts
[My only regret is that I have... boneitis.](https://www.youtube.com/watch?v=4O1TbUHGN_k)
Comment · Sat, November 19, 2022 · 45 pts
I've been taking it daily for quite some time. It's really nice for mood and cognition. It pairs very well with dopaminiergic compounds, especially at double the usual dose. Sabroxy is a good one to pair it with. Also, w
Comment · Sat, November 19, 2022 · 22 pts
Depends on the demand. I can't predict that. However, we are pretty sure we should be fine on supply for the short/medium term. If it takes off better than we anticipate, we will have to jump quickly to another productio
Comment · Sat, November 19, 2022 · 19 pts
Many years of work, but it is finally here!
Comment · Sat, November 19, 2022 · 21 pts
I am hoping for sometime in January for that one!
Comment · Sat, November 19, 2022 · 16 pts
Still doing some work on multiple of the ingredients we are going to use. We have a very tentative formulation, but we are trying some novel extraction techniques to see if we can get unique compounds out of the plant. I
Comment · Sat, November 19, 2022 · 12 pts
No, and I have cycled off a few times to see if there was any rebound. It's super functional at the dose we set. Perhaps if you go higher in dose you might, though.
Comment · Sat, November 19, 2022 · 11 pts
The effects build up, so you will see the most benefits in daily dosing over a couple weeks. However, there are acute effects. I notice them for 6-8 hours. I only dose once per day, and I do that mid day. I always dose o
Comment · Sat, November 19, 2022 · 10 pts
I have combined it with pretty much everything you can think of. Nothing so far has jumped out as a clear combo to stay away from.
Comment · Sat, November 19, 2022 · 20 pts
Yes, that is part of what took so long.
Comment · Sun, November 20, 2022 · 28 pts
You are correct!
Comment · Sun, November 20, 2022 · 9 pts
Includes alcohol, but usually at least spaced a few hours apart.
Comment · Sun, November 20, 2022 · 10 pts
Do you think we would just leave dopamine out of the party?!? It needs tickles, too! Plus, activating multiple receptor systems in the right balance is what really brings the magic. I do want people to put this bacopa in
Comment · Sun, November 20, 2022 · 10 pts
100% functional. Microdosing is all about sub-threshold doses resulting in mood and cognition improvements over time. The issue is many people these days are not really microdosing. They are just low dosing, but still ov
Comment · Sun, November 20, 2022 · 11 pts
That's the big issue right now. Most people microdosing are not actually doing that. They are just low dosing, but still over threshold. It alters people expectations of effects and side effects. Real microdosing is supp
Comment · Sun, November 20, 2022 · 10 pts
We have the full video dropping this week. It was fun to shoot! We usually do a theme every year for Black Friday/Cyber Monday. This year we thought it would be cool to release our bacopa at the same time, and do a whole
Comment · Sun, November 20, 2022 · 12 pts
It's a special bacopa extract we made. It's legal everywhere, as it is a common plant sold all over the world, just done in a very specific way.
Comment · Sun, November 20, 2022 · 16 pts
Tribulus should be January.
Comment · Sun, November 20, 2022 · 12 pts
It's a patented bacopa extract that we have been working on for years. It's standardized to a compound that nobody else in the world is. I will leave that as a surprise for the release, though. The aim of this is to targ
Comment · Mon, November 21, 2022 · 16 pts
The interactions with 5-HT2A and mood/cognition are pretty complex, and are very dose-dependent. We are still learning a lot about how activation of 5-HT2A can affect downstream systems. https://biblio.vub.ac.be/vubirfi
Comment · Mon, November 21, 2022 · 6 pts
It shouldn't be, as what we have standardized to has no affinity for acetylcholinesterase. It's primarily targeting 5-HT2A and M1 muscarinic acetylcholine receptors.
Comment · Mon, November 21, 2022 · 7 pts
Yep, it is an agonist/PAM of the M1 receptor, and is slightly stimulating.
Comment · Mon, November 21, 2022 · 9 pts
Ours is a positive allosteric modulator of 5-HT2A, not a full agonist. This is a big difference. Also, it's much more complex than just activation of 5-HT2A. It's M1 ACh, BDNF, and reelin as well. Generally, down-regulat
Comment · Tue, November 22, 2022 · 6 pts
Yes, it is hitting multiple downstream mechanisms that affect memory.
Comment · Tue, November 22, 2022 · 5 pts
Yes, our new bacopa has more acute effects. They are also different effects than our 24%. This new one is actually a bit stimulating, so I take it in the morning or mid day.
Comment · Tue, November 22, 2022 · 8 pts
Correct. It should be less likely to cause that issue. In fact, I find it to be lightly stimulating.
Comment · Tue, November 22, 2022 · 4 pts
It doesn't appear to be in that database yet. USPTO are slow bois. I'll check with our patent attorneys to see if they know when/how long it takes them to disseminate things.
Comment · Tue, November 22, 2022 · 9 pts
Positive allosteric modulators increase the activation of a receptor without actually binding to the main site of the receptor. PAMs interact with binding sites that are distinct from the orthosteric site recognized by t
Comment · Tue, November 22, 2022 · 5 pts
I actually have. I have combined with 7,8-DHF as well. They seem to combine together very well. This one is certainly going to be going in some Natrium stacks later on.
Okay, so I am finally getting around to make a post about the results of some of the lab testing we have been doing. I've had the results for a bit, but I've been holding off on officially releasing them because frankly
Replying to MisterPaulAna · they should have a seperate research chemical company for laboratory and scientific development use only :)
The United States government tried to put me in prison for 20 years. They raided our facility with over 50 armed federal agents from 6 federal agencies. They held my team at gunpoint and tore apart our offices. They seiz
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After our recent release of Cyanidin 3-Glucoside, some concern was raised by Redditors regarding possible mycotoxin levels in it. I think some people in the industry have overhyped the risk of mycotoxin contamination, as
Many of our customers have been receiving emails from Amazon and other retailers/marketplaces discussing an important product safety notification. This safety notification is in regards to a nationwide recall from a larg