Where We're Going, We Don't Need Roads

Post · Sat, November 19, 2022 · 133 pts

Where We're Going, We Don't Need Roads

Comment · Sat, November 19, 2022 · 30 pts

I'mma let you finish... but the Tickler is the best of all time. ALL TIME, MAN!

Comment · Sat, November 19, 2022 · 19 pts

[My only regret is that I have... boneitis.](https://www.youtube.com/watch?v=4O1TbUHGN_k)

Comment · Sat, November 19, 2022 · 45 pts

I've been taking it daily for quite some time. It's really nice for mood and cognition. It pairs very well with dopaminiergic compounds, especially at double the usual dose. Sabroxy is a good one to pair it with. Also, w

Comment · Sat, November 19, 2022 · 19 pts

Many years of work, but it is finally here!

Comment · Sat, November 19, 2022 · 21 pts

I am hoping for sometime in January for that one!

Comment · Sat, November 19, 2022 · 16 pts

Still doing some work on multiple of the ingredients we are going to use. We have a very tentative formulation, but we are trying some novel extraction techniques to see if we can get unique compounds out of the plant. I

Comment · Sat, November 19, 2022 · 12 pts

No, and I have cycled off a few times to see if there was any rebound. It's super functional at the dose we set. Perhaps if you go higher in dose you might, though.

Comment · Sat, November 19, 2022 · 11 pts

The effects build up, so you will see the most benefits in daily dosing over a couple weeks. However, there are acute effects. I notice them for 6-8 hours. I only dose once per day, and I do that mid day. I always dose o

Comment · Sat, November 19, 2022 · 10 pts

I have combined it with pretty much everything you can think of. Nothing so far has jumped out as a clear combo to stay away from.

Comment · Sat, November 19, 2022 · 20 pts

Yes, that is part of what took so long.

Comment · Sun, November 20, 2022 · 28 pts

You are correct!

Comment · Sun, November 20, 2022 · 9 pts

Includes alcohol, but usually at least spaced a few hours apart.

Comment · Sun, November 20, 2022 · 10 pts

Do you think we would just leave dopamine out of the party?!? It needs tickles, too! Plus, activating multiple receptor systems in the right balance is what really brings the magic. I do want people to put this bacopa in

Comment · Sun, November 20, 2022 · 10 pts

100% functional. Microdosing is all about sub-threshold doses resulting in mood and cognition improvements over time. The issue is many people these days are not really microdosing. They are just low dosing, but still ov

Comment · Sun, November 20, 2022 · 11 pts

That's the big issue right now. Most people microdosing are not actually doing that. They are just low dosing, but still over threshold. It alters people expectations of effects and side effects. Real microdosing is supp

Comment · Sun, November 20, 2022 · 10 pts

We have the full video dropping this week. It was fun to shoot! We usually do a theme every year for Black Friday/Cyber Monday. This year we thought it would be cool to release our bacopa at the same time, and do a whole

Comment · Sun, November 20, 2022 · 12 pts

It's a special bacopa extract we made. It's legal everywhere, as it is a common plant sold all over the world, just done in a very specific way.

Comment · Sun, November 20, 2022 · 16 pts

Tribulus should be January.

Comment · Sun, November 20, 2022 · 12 pts

It's a patented bacopa extract that we have been working on for years. It's standardized to a compound that nobody else in the world is. I will leave that as a surprise for the release, though. The aim of this is to targ

Comment · Mon, November 21, 2022 · 16 pts

The interactions with 5-HT2A and mood/cognition are pretty complex, and are very dose-dependent. We are still learning a lot about how activation of 5-HT2A can affect downstream systems. https://biblio.vub.ac.be/vubirfi

Comment · Mon, November 21, 2022 · 6 pts

It shouldn't be, as what we have standardized to has no affinity for acetylcholinesterase. It's primarily targeting 5-HT2A and M1 muscarinic acetylcholine receptors.

Comment · Mon, November 21, 2022 · 7 pts

Yep, it is an agonist/PAM of the M1 receptor, and is slightly stimulating.

Comment · Mon, November 21, 2022 · 9 pts

Ours is a positive allosteric modulator of 5-HT2A, not a full agonist. This is a big difference. Also, it's much more complex than just activation of 5-HT2A. It's M1 ACh, BDNF, and reelin as well. Generally, down-regulat

Comment · Tue, November 22, 2022 · 3 pts

I am the same. Sabroxy works fairly well for me, but I keep it to low doses to avoid side effects. This other one I really respond well to, though. I am just like you. I respond much better to releasers than re-uptake in

Comment · Tue, November 22, 2022 · 6 pts

Yes, it is hitting multiple downstream mechanisms that affect memory.

Comment · Tue, November 22, 2022 · 5 pts

Yes, our new bacopa has more acute effects. They are also different effects than our 24%. This new one is actually a bit stimulating, so I take it in the morning or mid day.

Comment · Tue, November 22, 2022 · 8 pts

Correct. It should be less likely to cause that issue. In fact, I find it to be lightly stimulating.

Comment · Tue, November 22, 2022 · 4 pts

It doesn't appear to be in that database yet. USPTO are slow bois. I'll check with our patent attorneys to see if they know when/how long it takes them to disseminate things.

Comment · Tue, November 22, 2022 · 9 pts

Positive allosteric modulators increase the activation of a receptor without actually binding to the main site of the receptor. PAMs interact with binding sites that are distinct from the orthosteric site recognized by t

Comment · Tue, November 22, 2022 · 5 pts

I actually have. I have combined with 7,8-DHF as well. They seem to combine together very well. This one is certainly going to be going in some Natrium stacks later on.