Comment · Fri, October 14, 2022 · ND Owner
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Original post in this thread
NDSocialMedia · 46 points
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What they were answering
redditintheAM · 5 points
Last time I checked the science around resveratrol was very questionable at best. Maybe I'll have to take another look.
u/MisterYouAreSoDumb · ND Owner
There are two studied calling into question the SIRT1 activation by resveratrol.
Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity (2009)
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1 (2009)
However, subsequent studies have come out to try and address those two, and found that it does activate SIRT1.
Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina (2018)
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism \(2021\)00729-8/fulltext)
Resveratrol and SIRT1 Activators for the Treatment of Aging and Age-Related Diseases \(2018\)
The role of sirtuin 1 and its activator, resveratrol in osteoarthritis \(2018\)
SIRT1 Activation by Natural Phytochemicals: An Overview \(2020\)
Modulation of SIRT1 expression improves erectile function in aged rats \(2022\)
Now there is definitely a feud going on between Flier/Brenner/Stanfield and Sinclair on this whole thing. Some of this feud is super sketchy to me, and involves a lot of money and patents, so I am suspicious of BOTH SIDES of this argument. However, there is a lot of data out there on resveratrol that was not run by Sinclair. For Flier/Brenner/Stanfield to be right, many researchers from multiple countries around the world would have had to all collude to put out bad data. I am not sold on that. Also, SIRT1 activation is only part of the story with resveratrol. You have AMPK activation. You have NF-κB effects. You have Cathepsin D effects. You have COX-2 and modulation of matrix metalloproteinases. Resveratrol is not just about SIRT1 activation. Also, the side effects that people are mentioning seem to be from extracts in lower standardization, which is why we went with 98%. We found GI upset issues at the 20% and 50% extract standardizations that most brands use, so that is probably a big part in it. You seem to want to stick to pure resveratrol.