Comment · Fri, August 5, 2022 · ND Owner
⚠️ NEW PRODUCTS ALERT | Maca Extract Capsules & Powder & OptiNAD Optimized Nicotinamide Adenine Dinucleotide Capsules⚠️
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NDSocialMedia · 89 points
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What they were answering
M30MM100 · 1 points
My understanding has always been that macaridine was the key bioactive compound in Maca that gave it its health benefiting properties. Am I incorrect on that and does this extract contain macaridine? Thanks again, I can’t wait to try it!
u/MisterYouAreSoDumb · ND Owner
Macaridine is supposedly an alkaloid in maca. Then you have other alkaloids, glucosinolates, thiohydantoins, macamides, and macaenes. Our extract we focused on the macamides and macaenes. There is no reference standard for macaridine, so we would have to do a lot of work to create methods for it. Saying that's the primary active wouldn't be correct. We just don't know enough yet to say for sure one over another. Also, there is a recent study showing macaridine was incorrectly identified and labeled in maca.
https://repository.uantwerpen.be/docstore/d:irua:6998
In addition, the structure of a previously reported compound named 'macaridine' was revised as macapyrrolin C based on density functional theory (DFT) calculations and comprehensive comparison of NMR data.
Thorough comparison of our findings and previous profiling studies pointed out several misinterpretations with regard to the imidazole alkaloids. From our point of view, it is crucial to restate that isolation and structure elucidation by NMR is the key to undoubtedly identify phytochemical constituents. To avoid misinterpretations, care should be taken in metabolomics research based on HRMS data, and tentative identification should only be carried out in combination with thorough proof.
So they are claiming the previous research on macaridine was incorrect, and it is actually macapyrrolin C.