Comment · Sat, July 30, 2022 · ND Owner
🔬Share Your Research Studies! Weekly Wednesday Discussion Thread🔬
Original post in this thread
NootropicsDepotGuru · 17 points
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Throw us your favorite research studies! Each Wednesday, we round up our favorite research study discoveries to share and discuss with the community on r/NootropicsDepot. Discover new studies, dig deeper into research, and present your findings from research studies about supplementation, nootropics, health, and fitness here on our weekly discussion thread.
What they were answering
TheOptimizzzer · 1 points
If the punicalagins aren’t metabolized into urolithin-A are they useful on their own or metabolized into a different useful compound? I wonder what the average conversion is and how much pomella someone would have to take to get a meaningful dose of urolithin-A?
For anyone else curious on this, for reference, by my math you can take ~16 capsules of pomella per day (2.4g, would be more if used powder) for the same price as one 500mg dose of timeline’s mitopure urolithin A. So the conversion has to be ~20% for equal value, that is if we exclude all of the other benefits we’re likely getting from the rest of the pomella.
I’m not recommending people take that much pomella …lol, just a thought exercise, though I doubt it would have bad effects. More has always seemed to be better for me with pomella (I’ve gone as high at 900mg per day). Might be a good argument for those big bottles 😏.
u/MisterYouAreSoDumb · ND Owner
Yeah, that's the problem with urolithin-A. It costs a ton. We considered offering it, but it would be one of the most expensive products we offered. It's hard to say how much urolithin-A you will get with a big dose of Pomella. It's going to depend on the person. If you go by Mitopure's data, it doesn't seem a massive amount higher.
https://www.nature.com/articles/s41430-021-00950-1
The analysis showed that circulating levels of UA glucuronide were significantly higher (p < 0.0001; 2.4-fold higher mean level) with Mitopure supplementation compared with drinking PJ (Fig. 4B).
The plasma levels of UA glucuronide (mean iAUC; p < 0.0001) as assessed by the 6 and 24 h time points (Fig. 5A) were six-fold higher in the Mitopure group than the PJ group.
So taking 500mg Mitopure resulted in somewhere between 2.4 and 6 times higher urolothin-A than drinking pomegranate juice. Pomella is going to give you a lot more punicalagins than drinking pomegranate juice would, so I would imagine UA levels would be higher than that. So the difference between Mitopure and Pomella should be <6X. I'd love to see a pharmacokinetic study comparing 500mg of Mitopure with one capsule of Pomella and six capsules of Pomella.