🔬Share Your Research Studies! Weekly Wednesday Discussion Thread🔬

Comment · Wed, July 27, 2022 · 12 pts

https://www.frontiersin.org/articles/10.3389/fphys.2020.00730/full I totally missed this mechanism for the past couple years! Seems like a big deal in both the acute and long-term side effect profile! https://www.natur

Comment · Wed, July 27, 2022 · 6 pts

Pomella is standardized to punicalagins, which metabolize to urolithin-A in the Gi tract.

Comment · Thu, July 28, 2022 · 2 pts

Are you on other things that hit AMPK?

Comment · Thu, July 28, 2022 · 5 pts

Yes, but that seems to happen to a reasonable level. https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.202101019 Metabolism of urolithin-A is the bigger hurdle. But yes, supplementing UA directly can get rid of one

Comment · Thu, July 28, 2022 · 3 pts

https://jme.bioscientifica.com/view/journals/jme/68/2/JME-21-0033.xml https://www.biorxiv.org/content/biorxiv/early/2020/04/10/2020.04.08.032607.full.pdf https://www.mdpi.com/2227-9059/9/5/492/pdf

Comment · Sat, July 30, 2022 · 3 pts

https://sci-hub.se/10.1021/acschemneuro.5b00260 Yeah, it's on Libgen. Using the DOI is the best way to find it.

Comment · Sat, July 30, 2022 · 3 pts

Yeah, that's the problem with urolithin-A. It costs a ton. We considered offering it, but it would be one of the most expensive products we offered. It's hard to say how much urolithin-A you will get with a big dose of P

Comment · Sat, July 30, 2022 · 7 pts

Yeah, the NMN, NR, and quercetin mixed with carnosine can cause the anxiety. I've experienced it, too. It's the AMPK activation. I would add in some apigenin, L-theanine, and Micromag to help balance that out.

Comment · Sat, July 30, 2022 · 3 pts

Yeah, I'd love to see a study! Urolithin-A is just so expensive. It's hard to justify.

Comment · Fri, August 5, 2022 · 1 pts

Yeah, the data is not conclusive. I am just going off my personal experience. Too many AMPK activators gives me anxiety. I know there is some data on using a single AMPK activator to lower anxiety, but they didn't look a

Comment · Fri, August 5, 2022 · 2 pts

That's actually what I do. I take baikal skullcap midday, then apigenin by itself in the evening.

Comment · Fri, August 5, 2022 · 1 pts

Depends on if you are benefiting from the AMPK activation or not. I would say add in the others to balance it out, as the benefits from AMPK activation warrant keeping that going.

Comment · Fri, August 5, 2022 · 2 pts

I have not. If you can find the study, please link it!

Comment · Wed, August 10, 2022 · 3 pts

Quercetin, hesperidin, berberine, NMN, CoQSol-CF, EGCG, epicatechin, nobiletin, curcumin, etc.

Comment · Thu, August 11, 2022 · 2 pts

It's not. Beta-ecdysterone is 20-hydroxyecdysone, so a different molecule. Close, but not the same.

Comment · Mon, August 15, 2022 · 2 pts

Noted!