Comment · Wed, July 27, 2022 · Natrium Health & Nootropics Depot
Is NALT (N-Acetyl L-Tyrosine) really just placebo?
Original post in this thread
TheNootropicist · 4 points
So according to a study I've seen mentioned frequently, NALT is a waste of time and money, because it has poor bioavailability. But it also seems that surprisingly many say that it does work, some even say that it works better than regular L-Tyrosine. Even MisterYouAreSoDumb says this. I am very confused. The NALT-supporter camp says that the study is outdated. On the other side, someone even said that NALT sucks because "even" IV administration leads to poor bioavailability, and then others said that NALT is a prodrug, meaning that it can raise L-Tyrosine levels, but why would you use this when you can just get the regular Tyrosine? Then people also say that it works better because it is more water-soluble, but isn't lipophilicty (for large molecules) a factor that predicts BBB crossing, meaning that the less water-soluble L-Tyrosine would be better? So is NALT really just a sugar pill or does it work to some degree?
What they were answering
ZestycloseGate7928 · 1 points
Bad day at work buddy ? "dimwitted Jabroins" ? I'm several years into nootropics, tested almost all products in Your shops. Nalt didn't work for me at all except two first times. It is so called "placebo effect" . I had this with bunch of substances. So im just dimwitted Jabroin i guess..
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
Just because a specific thing didn't work for you doesn't mean it is just placebo for everyone else that it does work for. That was my point. There are supplements I personally don't react to, but I know other people do. I wouldn't call them placebos just because my individual body/brain didn't react to them. My tone is more to do with the frustration of ten years of people saying NALT is bullshit, and anyone selling it is just selling placebo, when I know it works for many. There are a lot of people out there that read one study, then parrot around things like they are settled fact, when the science is far from settled.