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Comment · Tue, June 7, 2022 · ND Owner

Anyone try the saffron yet?

What they were answering

MF3DOOM · 1 points

I have read studies mentioning saffron’s effect on dopamine and norepinephrine, where did you read about it affecting the 5-HT system?

u/MisterYouAreSoDumb · ND Owner

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068454/

Rats that received saffron treatment combined with exercise had significantly greater brain-derived neurotrophic factor (BDNF) and serotonin in hippocampus compared to the control and saffron-only-treated rats (p< 0.05). Neurotrophin-3 mRNA in soleus muscle was higher in the saffron plus exercise group than rats in the other three groups (p< 0.05). Hippocampus 5-hydroxyindolacetic acid and short-term memory were significantly greater in all the intervention groups than in the control group (p< 0.05).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637901/

Hosseinzadeh et al (3) revealed that safranal owns significant antidepressant properties in a mouse model. In this research, an increase in swimming time in forced swimming test was thought to be related to amplified synaptic serotonin as it happens with fluoxetine.

https://pubmed.ncbi.nlm.nih.gov/33556410/

Six weeks of RT combined with saffron supplementation improved AEA, 2-AG, dopamine, β-endorphin, and serotonin concentrations. Moreover, the addition of saffron supplement to chronic RT results in greater improvements in happiness levels than RT alone.

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