Comment · Fri, April 29, 2022 · ND Owner

Will you ever release l-carnosine in caps?

Original post in this thread

hemannjo · 10 points

Massively underrated supplement in my opinion too btw.

What they were answering

Hormesis · 1 points

Hmm, no, I haven’t taken it with reduced glutathione at the same time. I tried the reduced glutathione for a while as well, which also made me feel acutely depressed. Again, I know these reactions aren’t typical.

u/MisterYouAreSoDumb · ND Owner

So I was talking it over with /u/Pretty-Chill and we think we have a theory. So carnosine, glutathione, and homocarnosine all use the same peptide transporter in the body. Taking carnosine and glutathione could be blocking homocarnosine. This could be leading to the depressive symptoms you are getting.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627134/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912684/

It could be related to an inhibition of PEPT-2 by carnosine and glutathione, which is reducing homocarnosine in the brain.

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