Comment · Mon, April 25, 2022 · ND Owner

Will you ever release l-carnosine in caps?

Original post in this thread

hemannjo · 10 points

Massively underrated supplement in my opinion too btw.

What they were answering

Hormesis · 4 points

I’ve tried this one a handful of times over the past 10 years, and I always feel amazing for a few weeks, and then deeply depressed. Any thoughts on what might cause that? I know that’s not typical, and I would love to continue taking it. I get a massive energy boost.

u/MisterYouAreSoDumb · ND Owner

I wonder if it is due to the competitive inhibition of uptake of other peptides?

https://sci-hub.se/10.1042/cs0460707

So it could be carnosine preventing the uptake of other things after a while. Maybe shorter cycles of it, or taking carnosine in the AM and glycine and other aminos in the PM, could prevent it. So maybe do 5 days on and 2 days off. Also, have you tried taking it with reduced glutathione? That should help the bioavailability.

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