Comment · Sat, April 16, 2022 · ND Owner
Original post in this thread
hemannjo · 10 points
Massively underrated supplement in my opinion too btw.
What they were answering
Fruitdawg · 1 points
Would the 250mg dose with glutathione be enough to elicit the exercise boosting benefits of L-carnosine?
u/MisterYouAreSoDumb · ND Owner
I'd probably say 500mg carnosine and 500mg reduced glutathione would be a good dose, actually.
Comment · Thu, April 14, 2022 · 11 pts
No, beta alanine cannot make enough L-carnosine to overwhelm your carnosinase enzyme, because the conversion of beta alanine is also rate-limited. Beta alanine is good for keeping steady carnosine levels. However, if you
Comment · Thu, April 14, 2022 · 10 pts
It's honestly one of the best antiaging supplements for people, but it always goes overlooked. I've wanted to put them in capsules for a while, but it is expensive and a slow seller. We have been waiting for the right ti
Comment · Fri, April 15, 2022 · 4 pts
Low volumes and because it is a dipeptide. The synthesis of peptides is usually more expensive, and since it is not a highly in-demand product, economies of scale do not come into play as much. However, a new paper was j
Comment · Fri, April 15, 2022 · 6 pts
One gram is about what you need to take to overwhelm carnosinase on its own. However, we did find that NAC and glutathione can lower that. In theory, you should be able to take like a 250mg dose if you combine it with NA
Comment · Sat, April 23, 2022 · 1 pts
Time of day shouldn't matter too much. I have been taking it in the morning with reduced glutathione.
Comment · Sat, April 23, 2022 · 2 pts
Hmm, really good for a few weeks, then depressed? I will have to research a bit. I personally can get overstimulated with it, if I have a lot of other AMPK activating things in my stack. It hits AMPK well. I would imagin
Comment · Mon, April 25, 2022 · 1 pts
I wonder if it is due to the competitive inhibition of uptake of other peptides? https://sci-hub.se/10.1042/cs0460707 So it could be carnosine preventing the uptake of other things after a while. Maybe shorter cycles o
Comment · Fri, April 29, 2022 · 1 pts
Interesting!!! Glutathione making you depressed? Well that is a strange one! I wonder if taking glutathione with the carnosine at the same time in the AM would counteract that effect?
Comment · Fri, April 29, 2022 · 3 pts
So I was talking it over with /u/Pretty-Chill and we think we have a theory. So carnosine, glutathione, and homocarnosine all use the same peptide transporter in the body. Taking carnosine and glutathione could be blocki
Comment · Thu, August 18, 2022 · 2 pts
I actually really like it. If you are combining it with OptiNAD+ and Clairmag, you will get a nice balanced effect from the stack.
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