Comment · Fri, October 22, 2021 · ND Owner
Reddit AMA | In-House Lab Edition
Original post in this thread
NootropicsDepotGuru · 77 points
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We are very excited to announce that Nootropics Depot will be conducting its first-ever Reddit AMA (Ask Me Anything), which is a semi-live Q&A session, about our In-House Analytical Laboratory and we would love for you to join us! See below for full details and get your question(s) ready. We hope to see you there!
WHEN
STARTS: October 20th | 9am AZ MST
ENDS: October 22nd | 9am AZ M…
What they were answering
yungtommyguns · 1 points
I'm confused as to what to think of the quality of your fish oil products. Can you expand on this? Let's use the Triple Strength softgels as reference. Is there a reason they are not in the reesterified triglyceride oil form? Ethyl ester is the same form as most other fish oils on the market which are cheap; and the form is often not very bioavailable and is more prone to oxidation. I see the fish source of the Triple Strength product says anchovy or tuna. While anchovy should generally be a fairly safe source, tuna might not be due to it being predatory/large. Should the level of potential contaminants not be a concern due to your molecular distillation process? Please advise, including any info I may be missing.
u/MisterYouAreSoDumb · ND Owner
I've talked about it in detail before.
I also discussed it a bit on the Accelon post.
https://www.reddit.com/r/NootropicsDepot/comments/jnhuj0/new_product_alert_accelon_omega_3_fish_oil/
Moral of the story is that triglyceride forms are more acutely bioavailable, but fall off on the AUC faster. Not to mention they are more expensive, and the increase in bioavailability is not enough to justify the cost. Taking more EE fish oil makes more sense from a length of effect standpoint and a monetary standpoint. People selling triglyceride forms try really hard to make people believe they are so much better, but the data doesn't show that. Triglyceride forms are more bioavailable, but only by like 10-30%. It's usually not enough to justify the cost increase of putting them back into triglyceride forms. Your body converts the ethyl esters back into triglyceride forms after absorption anyway, so there will be no difference in how the omega-3s act once in the body. If it were the same price I would say go for the triglyceride, since then you would be getting more into your body. However, if they are way more expensive, just stick to ethyl ester.
While anchovy should generally be a fairly safe source, tuna might not be due to it being predatory/large. Should the level of potential contaminants not be a concern due to your molecular distillation process? Please advise, including any info I may be missing.
We test every single batch for contaminants, so we verify it in the lab. The molecular distillation process does remove anything in there, but you don't just trust it. You verify it in the lab every time. Fish oil is one of our most rejected products. We probably reject more batches of fish oil than anything else, due to how susceptible to contaminants and oxidation they are. Only the batches that meet our stringent specs will be approved and sold to customers.
So in short, I would sell triglyceride forms if they were not insanely more expensive than ethyl ester forms. The cost does not justify the massive increase in price, and ethyl ester forms will have a longer-lasting effect in the body, due to their pharmacokinetics. It makes more sense to take a larger dose of properly tested ethyl ester fish oil.