Skip to content
MYASDArchive
Archive/r/NootropicsDepot

Comment · Tue, October 19, 2021 · ND Owner

NMN out of stock, darn!

Original post in this thread

pantsnot · 16 points

Any ETA?

What they were answering

readhere2 · 1 points

Thanks. Interesting because dopamine is what started my path to ND (you). I didn’t realize that some stims deplete dopamine. I haven’t looked at your Happy stack most recently but what is your number one pick for dopamine boost?

FYI-Unless I’m experiencing a placebo effect with the Polygala it seems to have a very positive effect on me in terms of depression and/or lack of dopamine. My re-order is on its way and just being without it for less than a week I’m feeling a substantial drop.

u/MisterYouAreSoDumb · ND Owner

Uridine increases DA levels and up-regulates DA receptors. That's why it is a good one for nightly use. You are not crazy with the polygala, though. That is a really great one for mood boosting, and it does it through multiple pathways. Dopamine is one of those pathways, but so is BDNF, 5-HT2A, and norepinephrine.

Other MYASD lines in this thread

Related in the archive

Commentr/NootropicsDepotJul 19, 2020

Immune Defense & positive blood test results

Replying to sirsadalot · I began using kratom because I thought it was harmless and mostly beneficial. I used small doses of 3 grams 3 times a day for a year straight. This led to an extreme increase in de…

Bromantane is okay. It's not the miracle some people make it out to be. Why are you thinking it is a dopamine synthesis issue? It's likely a down-regulated receptor issue. Uridine can help up-regulate dopamine receptor

5PolygalaAgmatineUridineCordyceps
Commentr/NootropicsDepotFeb 12, 2022

Possible to get an update on the referenced in conjunction with stimulants stack?

Replying to TheOptimizzzer · u/misteryouaresodumb

Oversimplifying it a bit, but: **Reducing tolerance build up from the stimulants.** * Micromag * Agmatine Sulfate * Triacetyluridine * Polygala **Optimizing neurochemistry/dopamine signalling.** * L-tyrosine * Triac

14BacopaLion’s maneCistancheAshwagandha
Commentr/NootropicsDepotAug 22, 2020

Feedback on stack: Polygala, NMN, Aniracetam, Tongkat 2%

Replying to ianonuanon · There are no herbal testosterone boosters that increase testosterone to any appreciable level (substantial enough to make a difference in ability to gain and maintain muscle mass).…

[Phytoandrogenic properties of Eurycoma longifolia as natural alternative to testosterone replacement therapy](http://booksdl.org/scimag/get.php?doi=10.1111/and.12214&key=Z4OU9H8ZORJRV6IP) [Effect of Tongkat Ali on stre

13AniracetamTongkat aliPolygalaRacetams
Commentr/NootropicsDepotJul 25, 2020

Should I be worried about Magnolia Bark Extract and dependency/withdrawal issues?

Replying to YoYoYL · Good question, not all of them provided more specific info. There's that: [https://onlinelibrary.wiley.com/doi/10.1002/hup.2595](https://onlinelibrary.wiley.com/doi/10.1002/hup.25…

Withdrawal from URIDINE?!? Maybe those people are just really sensitive to GABAergics. That study you linked is silly. They Googled shit and wrote a meta analysis on it. They even say no actual peer-reviewed research h

9PolygalaUridine
Commentr/NootropicsDepotApr 22, 2021

Supply chain breakdown risks for Nootropics Depot?

Replying to Fallonsfox26 · Are there any of your products that might be difficult to get in the near future? I was going to wait to put in an order until Monday but now I’m thinking it might not be wise to w…

It's hard to say. NMN, polygala, gotu kola, adrafinil, and a few others are out of stock right now. Polygala was released today, though. NMN is in production. We were supposed to have a sample of the finished tablets las

8ModafinilPolygalaNMN
Commentr/NootropicsDepotJul 30, 2020

Can Berberine Cause Hypoglycemia?

Replying to RSGC9 · Great topic because I wanted to ask you guys at ND about this. I've done alot of research into weight loss maintenance and fitness etc, and there is a huge genetic difference betwe…

Genetics plays a huge role. I am one of those that has to watch what I eat closely or I will gain weight. I can put on weight, both fat and muscles, easily. However, it is much harder for me to lose it. Whereas my friend

7Tongkat aliPolygalaAgmatinePeptides