Comment · Mon, January 4, 2021 · ND Owner
Accelon Omega 3 water solubility versus regular fish oil
What they were answering
1337WhizzKid · 3 points
Any idea if the technology they use works similarly to the phospholipid form of DHA/EPA? I’m an APOE4 carrier so I stick to phospholipid forms of EPA and DHA based on this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338661/
I’ve previously reached out directly to Accelon but didn’t receive a reply.
u/MisterYouAreSoDumb · ND Owner
Yes, it should in theory work better to transport the omega-3s across the BBB, due to the lipid micelles that are formed. I am not sure if BASF has studied that directly yet, though. However, it has been theorized that some of the less-than-promising results from some clinical studies on fish oil were because they were using ethyl ester forms without eating a meal at the time of dosing. The paper you linked discusses the possibility that they need to be in phospholipid form to cross the BBB, but it could also be an oral bioavailability issue, too. The Accelon human clinical trial discusses how the fish oil circulates as the triglyceride form after passing through the lymphatic system as components of chylomicrons, which then also can form into phospholipid forms in the liver.
This study talks about how EPA and DHA cross the BBB: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joim.12166
So it might mostly just be a factor of bioavailability and absorption, and strictly being in the phospholipid form isn't necessary.