Comment · Sat, January 2, 2021 · ND Owner
does ECGC/green tea extract make you tired?
What they were answering
umbrella_term · 2 points
Hm, that's in vitro, so I looked it up a bit. I see this study Effects of 2 Adenosine Antagonists, Quercetin and Caffeine, on Vigilance and Mood did not reach significance when administering as much as 2000 mg of quercetin.
Semi-relatedly, this one shows that quercetin reduced the area-under-curve of caffeine and paraxanthine. Shame they didn't also do any kind of alertness tests in the co-administration group. Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C (-2964G>A) and *1F (734C>A) gene polymorphisms
u/MisterYouAreSoDumb · ND Owner
For sure. You can't directly apply the in vitro study and say it has the same effects in vivo. However, we know the mechanism is there, and I can tell you from experience that our quercetin does add stimulation. It can actually make things too much in some scenarios, like with berberine, NMN, CoQ10, ALA, and caffeine in the mix. Also, my product specialist uses quercetin in place of caffeine on days when he wants a smoother stimulation. So it is a factor. As to the relative potency/efficacy in relation to other adenosine antagonists, it's hard to say for certain. It would be nice to have a clinical study on the matter to get some actual data.