Comment · Fri, November 27, 2020 · ND Owner
⚠️ New Product Alert ⚠️ Nicotinamide Mononucleotide Enteric Coated Tablets | 125mg
Original post in this thread
NootropicsDepotCom · 25 points
What they were answering
juantoconero · 1 points
Sorry to respond on this old post, but studying NMN as a possible addition to my mom's stack and saw this from Rhonda Patrick:
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Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD+ salvage pathway that converts nicotinamide to nicotinamide mononucleotide. Both NAMPT and nicotinamide mononucleotide might have pro-angiogenic activity (the capacity to build blood vessels) and support the growth of some types of cancers. For example, in a mouse mammary carcinoma model, pharmacologically inhibiting NAMPT delayed tumor growth with a dose-dependent decrease in NAD+levels.[\[18\]](https://www.foundmyfitness.com/topics/nicotinamide-mononucleotide#bibid-76a1cf992658e7821c6cd00b189b1225)
Furthermore, NAMPT and nicotinamide mononucleotide have been associated with cellular senescence – the growth arrest of cells – which may lead to aging and cancer. In a mouse model of pancreatic cancer, proinflammatory senescent cells drive tumor growth. When mice were injected with 500 mg/kg/bw of nicotinamide mononucleotide for 13 days, they exhibited significant increases in precancerous and cancerous lesions in the pancreas. Conversely, treatment with a NAMPT inhibitor suppressed proinflammatory and senescent markers while decreasing precancerous and cancerous lesions.[\[19\]](https://www.foundmyfitness.com/topics/nicotinamide-mononucleoti…
u/MisterYouAreSoDumb · ND Owner
No more than any other compound that increases things used in the propagation of cells, like NGF, BDNF, ATP, telomeres, etc. Cancer cells are cells, in that they use the same types of compounds to grow and spread. Increasing things that help healthy cells survive and propagate can certainly also help cancer cells do the same. You get cancer cells in your body every day. It's just a fact of life. Your body's immune system just finds them and destroys them before they can get out of hand. So sure, you might consider taking some pro-immune supplements alongside supplements that increase things that lead to more cellular growth. Your immune system is the real defense against cancer.