What are you going to do when your adrafinil storage runs dry?

Fill a swimming pool with them, then dive in like Scrooge McDuck! LOL

Actually, some people prefer the darker adrafinil. Particle size and crystal structure doesn't really affect the bioavailability or effects of most things. That's because they go into solution in the GI tract most of the time. However, there are things that are just not soluble in much. Adrafinil is one of those things. So since it has strange solubility, the particle structure and size might have an effect on how fast your body can absorb it. It's called a polymorph, and pharma companies spend a lot of money on them. The main issue is they keep what they learn as trade secrets. So it is VERY hard to find information on polymorphs of various compounds, and how that affects the effects. Cephalon does control for polymorphs, though. I know that for a fact. This is why I have been trying to figure this shit out since the early Ceretropic days, when we offered both the light and dark adrafinils. It's a physical science, though. It's not chemistry. So finding people qualified to help with it is next to impossible. They are all working at pharma companies with NDAs. This is why it has taken me so long to solve this issue.

We did all sorts of analyses on adrafinil over the years. NMR, ICP-MS for various metals like iron and chromium, polarimetry, etc. We thought that maybe it was the iron content of the batch making it pink, since iron can lead to that color sometimes. However, we tested like 10 different batches of white and pink adrafinil, and found no correlation to iron content. We found chromium content differences, but they did not correlate with the color. We did NMR analysis to see if there were any unreacted compounds left in there resulting in the color, but found nothing else. Both the white and pink batches were pure. We did polarmiter testing to see if perhaps there was a ratio difference in the isomer content, as you can have R and S forms. Nope... all racemic. They bent polarized light the exact same. We spent a ton of time and money trying to figure this whole thing out. It wasn't till we started doing our own syntheses of adrafinil that we could control the process enough to test some of our theories. We don't have an X-ray crystallography machine in our lab, and very few labs do, either. So we had our suspicions for a couple years now, but we only recently proved it by trying different crystallization steps. We are now going to go down that path of polymorphs and crystal structure, as I think we can improve the effects and absorption of many synthetic compounds this way! I think this could be the reason some people say one batch works and another doesn't as much, even if they are the same purity. It could be the crystal structure! Now this would only affect poorly-water-soluble things. If it is water-soluble, crystal structure won't matter because it will just go into solution in the GI tract. However, it could make a difference in things that have poor solubility.

Our synthetic chemist did say he is going to make us a single 1kg pink crystal of adrafinil, which we will then laser etch our ND logo into. LOL. I will then proudly display this massive pink adrafinil crystal at our facility in a glass case, as an reminder of our victory over the adrafinil color mystery!