Comment · Thu, August 13, 2020 · Natrium Health & Nootropics Depot
Two clinical trials support GABA’s cognitive health benefits
Original post in this thread
ProperBeat · 59 points
Supplementation with GABA (gamma-aminobutyric acid) may boost a range of cognitive measures, including memory and spatial cognitive function, according to two new studies from Japan.
The results showed that 12 weeks of GABA supplementation at 100 mg per day led to significantly better tests scores for visuospatial/construction faculty and memory, and when the dose was doubled to 200 mg, additional improvements were recorded.
Note: both studies were funded by Pharma Foods International, which produces its GABA from the fermentation of Lactobacillus hilgardii using a proprietary process to over 80% purity, according to the company. The ingredient PharmaGABA, which is self-affirmed GRAS in the US, reportedly commands over 80% of the Japanese market.
What they were answering
Al_K_Mist · 2 points
I thought this study might interest you in relation to phenylpiracetam hydrazide (reference at end).
Isoniazid, the hydrazide of iso-nicotinic acid, administered in high doses has been observed to increase whole brain GABA in mice. The authors theorized hydrazine, the hydrolysis product of INH, was responsible.
They found hydrazine (5 micromolar) was capable of inhibiting GABA aminotransferase’s enzymatic activity by 50% without affecting glutamic acid decarboxylase.
Furthermore, low dose hydrazine injections (.08 mmol/kg/day) significantly increased whole brain GABA levels in mice (data not listed in abstract).
I don’t know if a metabolic study of PPH was ever conducted, but I’d be interested to see if hydrazine was a major metabolite. The dosage of isoniazid (300 mg daily) is higher than a typical PPH dose (~150 mg) and isoniazid was far less potent than hydrazine, itself, so contribution of PPH’s metabolites would be low. Still an interesting question to consider for research nootropics.
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.1981.tb05287.x
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
That is really cool!