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Comment · Thu, August 6, 2020 · ND Owner

Berberine and Testosterone

Original post in this thread

varvela · 7 points

I recently came across this study finding that Berberine significantly lowered testosterone in women with PCOS.

I mainly take Berberine once at night for longevity reasons (AMPK regulation), but am concerned now that it could have adverse testosterone effects.

Does anyone have further information on this?

What they were answering

varvela · 2 points

Really appreciate the detailed answer! I figured from not being able to find discussions on it that it was a bad inference, but I didn’t want it sitting in the back of my head.

So thanks again, as soon as the new silymarin tablets and more potent Tongkat come I’ll be placing my next order 👍

u/MisterYouAreSoDumb · ND Owner

My pleasure! I really love berberine, and I am really excited to start back up on the new tablets we are releasing. Most people don't realize that berberine not only activates AMPK, but also sigma-1 receptors. So it is not just good for fat burning and insulin response, but also for energy and mood.

Pharmacological effects of berberine on mood disorders

Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes

Frankly, berberine is something that pretty much everyone would react well to after a certain age. I feel like it doesn't get enough credit for how much it positively affects.

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