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Comment · Mon, June 22, 2020 · ND Owner

⚠️ New Product Alert: LC-Plasma Capsules | A Novel Immune Support Supplement | Lactococcus lactis strain Plasma ⚠️

Original post in this thread

NootropicsDepotCom · 31 points

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LC Plasma | A Novel Immune Support Supplement

Backed by 7 efficacy studies and 2 safety studies, LC-Plasma (Lactococcus lactis strain Plasma) is a novel paraprobiotic that stimulates the body’s natural immune defenses. LC-Plasma activates pDC (plasmacytoid dendritic cells), a pivotal leader within the immune system... (click here to learn more)

Buy LC-Plasma Capsules from Nootropics Depot

What they were answering

AromaticAminoAcid · 2 points

Oh interesting so the cell wall is removed. Why’s that? That’s different than other heat-killed bacterial products, or Immuno LP 20 at least.

u/MisterYouAreSoDumb · ND Owner

So it gets complex. LC-Plasma activates the plasmacytoid dendritic cells (pDCs) through the TLR9-MyD88 pathway. MyD88, or myeloid differentiation primary response 88, is a protein downstream of the TLR9, or toll-like receptor 9. This protein is the canonical adaptor for the innate immune system, meaning that it can link the innate and adaptive immune systems together. Essentially this is a primary controller for the innate immune system and how it responds to pathogens. So how LC-Plasma activates the TLR9-MyD88 pathway is through its bacterial CpG motifs. CpG, which is short for 5'—C—phosphate—G—3', are short single-stranded DNA fragments in bacteria that have the cytosine and guanine separated by one phosphate group. Essentially they are unique single stranded DNA sequences in certain bacteria that have been shown to activate pDCs. So what we are looking to get into our systems from LC-Plasma are their CpG motifs, or bacterial DNA. We are not looking for live or even intact bacterial particles that then become a part of your system like with other probiotics. We are just looking to get their specific DNA into our systems so that it can activate the TLR9-MyD88 pathway, and modulate pDCs.

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