Comment · Mon, September 23, 2019 · Natrium Health & Nootropics Depot
Neuralstem stock now worth ~1/100 of that before announcing NSI-189 MDD efficiency 'failure'
Original post in this thread
ranza · 8 points
I just checked and it totally shocked me.
It looks like the hopes have been high, but it really takes a long time to deliver the product.
Previously they've stated that:
> [ NSI-189] .. did not meet its primary efficacy endpoint of a statistically significant reduction in depression symptoms on the Montgomery-Asberg Depression Rating Scale (MADRS)
However, given an over one standard deviation improvement in memory with high confidence and other (quite big improvements) (wikipedia):
> Of particular note are improvements in memory (effect size Cohen's d = 1.12, p = 0.002), working memory (d = 0.81, p = 0.020), and executive functioning (d = 0.66, p = 0.048) as measured by the CogScreen computerized test.
I find it very weird that they didn't yet commercialize the product for any other (say, nootropic) purpose.
What do you think is happening?
What they were answering
ebowden · 2 points
Ah, right, couldn't hope for even the piecemeal IP to be THAT cheap despite the crash. As far as new products that fit with the new "natural extract" direction you are going in, have you considered doing fibroin hydrolysate? It has had interesting effects on working memory, long term memory and attention in human clinical trials, on both children and older adults. There's a paper on how to produce the stuff they used "Brain Factor 7", but it's in Korean, so you would have to get someone to translate for you.
Swanson sell bottles of 60 200mg caps, which does coincide with the doses used in many of the trials.
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
No, actually! I will have to read up on it.