Comment · Thu, December 21, 2017 · Ceretropic & Nootropics Depot
ITPP (Myo-Inositol TrisPyroPhosphate) for Alertness
Original post in this thread
__phoenix13 · 31 points
I recently received another shipment of ITPP (myo-inositol trispyrophosphate) as I had run out a while ago and wanted it for ski trips this winter.
For those not familiar, ITPP essentially increases the proportion of oxygen released from hemoglobin during each cycle through the cardiovascular system and back to the lungs, by acting as an allosteric effector to mildly reduce the oxygen binding affinity of hemoglobin. See, e.g.:
https://www.ncbi.nlm.nih.gov/pubmed/21086482
https://www.thermofisher.com/blog/proteomics/doping-control-myo-inositol-trispyrophosphate-itpp/
https://en.wikipedia.org/wiki/Altitude_sickness#Medications
The effects seem to last about a week or two, since it accumulates in red blood cells. Newly-produced RBCs will not have any, so periodic re-dosing is necessary to cover RBC turnover. See, e.g.: http://www.pnas.org/content/106/6/1926.full
I have seen some attempts in the community to use ordinary IP6 (myo-inositol hexaphosphate) for the same purpose, but IP6 cannot cross the RBC cell membranes due to its charge distribution so it is not useful when taken orally: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644140/pdf/zpq1926.pdf -- whereas ITPP can…
What they were answering
__phoenix13 · 1 points
I see.
Is this why you ultimately passed on SR9009 as well?
I just looked through the banned list and indeed there is a generic entry for "artificially enhancing the uptake, transport or delivery of oxygen." ITPP clearly enhances the delivery of oxygen. No specific mention but it seems strongly implied.
Granted, you do sell toremifene and raloxifene already.
(Interestingly, none of the racetams are listed, not even phenylpiracetam under stimulants -- although there is also a blanket ban on "all stimulants" not-otherwise-specified which sounds rather similar to the language applicable to ITPP under oxygen delivery above.)
Regardless, almost none of us are regulated competitive athletes.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
We are moving away from the risky compounds as a whole. If I even keep Ceretropic open, I am going to reduce what is on there even more. I would have offered it a few years ago. Now, we are just moving in a different direction.