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Comment · Thu, June 1, 2017 · Ceretropic & Nootropics Depot

Who can we get to synthesize this?

What they were answering

homosuperiorr · 7 points

I don't understand, it's totally bypassing a2 and a3 subunits (this one's which makes you fell good man) and binds strongly to a1 and a5 subunits (this amnestic and memory shiting ones) but it's still not addictive, mostly anxiolytic, and not impairing cognitive functions.

Wtf. someone explain pls. /u/MisterYouAreSoDumb

source

https://i.imgur.com/4eDA6Lz.png

https://i.imgur.com/G0PvNIS.png

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

It's a partial allosteric modulator. So it can actually reduce signaling, similar to a partial agonist. Since it seems to be reducing signaling at a1 and a5, that explains why it does not impair cognitive functions, and why it antagonizes diazepam. As to why it is causing anxiolysis, it's probably a compensatory mechanism. The brain up-regulates GABA because it sees lower activation at a1 and a5.

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