Comment · Thu, April 6, 2017 · Ceretropic & Nootropics Depot
Wow memantine is great!
Original post in this thread
Mine_Fuhrer · 30 points
I don't nosey around this sub but I thought this is where I should post this.
I've been using gabapentin, phenibut and gbl more than I should the past month save for a few days and I dosed two 2.5mg doses of memantine last night because I noticed the first dose doing something but not enough, the second curbed all discomfort and grogginess, this morning I woke up feeling the best I've woken up in months!
I feel right now, a few hours after waking, the same as I did before I got into the past months usage.
Some questions I've got:
+ How long is this sustainable?
+ Are there any other drugs that can help in ways like this with gaba drugs? (I've heard fasoracetam being kicked around, does it promise to do the same as memantine?)
+ Are there any consequences I may face for using memantine in combination with these drugs?
What they were answering
I_am_Jake_ · 1 points
GABA receptors have been demonstrated to be negatively coupled to adenylate cyclase via PTX-sensitive G-proteins. So this is how Fasoracetam reverses memory issues caused by baclofen and phenibut, and up-regulates GABAb receptors. It modulates adenylate cyclase, which are coupled to GABA by other G-proteins, leading to expression changes in GABAb receptors.
> Essentially Fasoracetam modulates the metabotropic glutamate receptors (mGluRs). The mGluRs are not ionotropic receptors like NMDA/AMPA, and do not directly control ion channels like other glutamate receptors. They are actually receptors that modulate downstream signal cascades, and affect other receptors and systems. This means they are not like activating ion receptors, and are not directly controlling influx of calcium/sodium/potassium into cells. They are modulating the excitability/expression of other receptors and ion channels, and affecting pre/postsynaptic responses.
One cool thing about Fasoracetam is how it affects the expression of the GABAb receptors. GABA receptors are actually negatively coupled to adenylate cyclase via PTX-sensitive G-proteins. Fasoracetam modulates adenylate cyclase, which consequently goes on to affect expression of GABAb. It is NOT directly binding to GABAb, and is not a G…
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Don't just trust my word for it.