Comment · Tue, December 27, 2016

Prl-8-53

Original post in this thread

nicholaslovellreno · 5 points

Hey guys, I have a question as to whether your supposed to cycle prl-8-53 or you can take it continuously without downregulation or tolerance buildup. I'm unfamiliar with its MOA.

I don't currently take it every day but have noticed substantial mood Improvement when I take it. It also might be important to note that when I take it I might be mega dosing, probably around 25mg.

I take approximately 40mg of nsi-189 a day, Memantine low dose daily probably around 7mg, and p21 daily approx 2mg.

When i decide to add PRL into this stack it gives me significant mood Improvement. Any info on what I should or shouldn't be doing concerning this is greatly appreciated.

Thanks

What they were answering

baronjpetor · 1 points

I've read somewhere that DMAE and acetylcholine both compete for the same transporters. If that's true, should centrophenoxine and Alpha-gpc be taken at different times?

u/MisterYouAreSoDumb

Some in vitro studies have shown that DMAE can inhibit the high-affinity choline transporter at certain concentrations. However, I am not sure that has been shown in vivo, or if it is a concern with taking choline precursors concurrently.

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