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Comment · Mon, June 13, 2016

Hydroxynorketamine

What they were answering

question2552 · 1 points

Aren't racetams ampakines? Shouldn't they have AD effects?

u/MisterYouAreSoDumb

Yes, some racetams positively modulate the AMPA receptors. However, the specific mechanism for Hydroxynorketamine's effects at the AMPA receptor are still unknown. It is probably a different mechanism/binding site, or a combination of its effects at the AMPA receptor and its inhibition of the alpha-7-nicotinic receptor. However, some people do report improvements in their depressive symptoms with certain racetams. It would be interesting to see if one takes an AMPAkine and an alpha-7-nicotinic antagonist together, whether or not they get strong antidepressant effects.

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