Comment · Mon, June 13, 2016
Hydroxynorketamine
What they were answering
Lavender131 · 1 points
Thanks for the response!
Makes sense. I look forward to you stocking it if you can. :)
I think it's really cool too. It's interesting to me that ampakines don't seem to have any antidepressant effects (from what I've read). I wonder if an AMPAR agonist would be any different. It's too bad that AMPAR agonists have the risks of seizures and excitotoxicity that they do.
u/MisterYouAreSoDumb
Well Hydroxynorketamine's action on the AMPA receptor is still an unknown mechanism. Perhaps there is a new binding site that we do not currently know about, or perhaps it is a combination of AMPA modulation, and inhibition of the alpha-7-nicotinic receptor. This modulation of AMPA could also be why some people get marked antidepressant effects from certain racetams. Ideally you would have a positive allosteric modulator of the AMPA receptor that would also depolarize if too much activation happens. So you can increase the activation when it is too low, but also decrease when it is too high. Then you would not have to worry about excitotoxicity.