Comment · Thu, March 31, 2016 · Ceretropic & Nootropics Depot
Has Tianeptine improved anybody's memory capacity? Or is it pretty much the case that it will be hindered?
Original post in this thread
Canibeyourdoctor · 14 points
Being depressed has shot my memory, but I am not looking to make this worse.
What they were answering
phuckwang · 1 points
Well the jury is still out on whether or not opioids are nootropic or not. I believe /u/MisterYouAreSoDumb cited a study that showed opioids actually increased neurogenesis but I could be totally wrong. All we know is that they aren't anti-nootropic like benzos or strong GABAergics are. The memory consolidation issues could stem from Tianeptine's NMDA activity which isn't well understood or it could come from Tianeptine's pro-adenosine properties (Tianeptine reverses the effects of caffeine). Personally, I think it's the opioid/dopamine properties that improve my memory. Opioids are basically a brain panacea for me. They induce a state of childlike wonder and excitement so it's no wonder I retain memories from opiate experiences. Tianeptine feels very similar to a low dose of psilocybin in that it's empathogenic, energizing, and enhances colors and emotions. Sorry, I'm kinda rambling on about it but out of the 30 antidepressants I've tried, Tianeptine has been a miracle drug.
I'm currently taking 2x40mg of Tianeptine Sulfate daily. I take one or two days off every other week just as a precautionary measure to avoid tolerance.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Opioid systems in the dentate gyrus
Opiate drugs alter cognitive performance and influence hippocampal excitability, including long-term potentiation (LTP) and seizure activity. The dentate gyrus (DG) contains two major opioid peptides, enkephalins and dynorphins, which have opposing effects on excitability. Enkephalins preferentially bind to delta- and mu-opioid receptors (DORs and MORs) while dynorphins preferentially bind to kappa opioid receptors (KORs). Opioid receptors can also be activated by exogenous opiate drugs such as the MOR agonist morphine. Enkephalins are contained in the mossy fiber pathway, in the lateral perforant path (PP) and in scattered GABAergic interneurons. MORs and DORs are predominantly in distinct subpopulations of GABAergic interneurons known to inhibit granule cells, and are present at low levels within granule cells. MOR and DOR agonists increase excitability and facilitate LTP in the molecular layer. Anatomical and physiological evidence is consistent with somatodendritic and axon terminal targeting of both MORs and DORs. Dynorphins are in the granule cells, most abundantly in mossy fibers but also in dendrites. KORs have been localized to granule cell mossy fibers, supramammillary afferents to granule cells, and PP terminals. KOR agonists, including endogenous dynorphins, diminish the induction of LTP. Recent evidence indicates that opiates and opioids also modulate other processes in the hippocampal formation, including adult neurogenesis, the actions of gonadal hormones, and development of neonatal transmitter systems.