Comment · Wed, March 30, 2016
Ocular delivery of peptides (Semax, Selank) with time release.
Original post in this thread
piracetam101 · 4 points
So I was thinking about a ROA for semax and selank that wasn't subQ or nasal and it dawned on me to research ocular dosing. The first study I found for ocular dosing of peptides is here:
So apparently there's these new microspheres called PLGA microspheres that can hold different drugs for different time releases for IV, ocular, and oral dosing.
The cost of these isn't that expensive either, only about $274.95 with an avg. diameter (µm) of 10 and 50mg of them. (Not expensive for a trial at least)
Source here:
http://www.phosphorex.com/degradexreg-plga-microspheres.html
The prep for these PLGA microspheres doesn't look that difficult either, outlined below
3.1. Microparticle Preparation Techniques
3.1.1. Solvent Evaporation Method
(1) Single emulsion process
Oil-in-water emulsification processes are examples of single emulsion processes. Polymer in the appropriate amount is first dissolved in a water immiscible, volatile organic solvent (e.g., dich…
What they were answering
achoowu · 3 points
What about delivery of these drugs where the sun don't shine?
u/MisterYouAreSoDumb
Rectal administration only bypasses 2/3 of first pass metabolism. So it is not nearly as efficient as nasal.