Comment · Tue, October 6, 2015 · Ceretropic & Nootropics Depot
Ceretropic's Oxytocin
What they were answering
sayitaintsoap · 5 points
Yeah, it's nothing to take lightly. Even though the syndrome isn't scientifically explained or medically recognized at the moment, the alarming number of anecdotal reports are enough to raise flags in my opinion. A pretty well written paper on probably the most widely accepted theory explaining the moa of the syndrome is here:
http://www.protocol-online.org/forums/uploads/monthly_08_2010/msg-19273-027408800%201282061244.ipb
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Wow, that definitely looks concerning. The mechanisms make sense, though. The sensitization, followed by rapidly returning baseline levels of DHT, could certainly be permanently affecting gene expression. That is one theory for the mechanism behind long-term tolerance to stimulants and opioids as well. Immediate early gene expression can be affected by too much calcium transmission into neurons. Reversing that is a difficult task.