Comment · Mon, September 14, 2015
SR-9009 (MoA)
Original post in this thread
Allan314 · 2 points
So I admittedly have a very superficial understanding of the mechanism of action of SR-9009. But I'm trying to wrap my mind around the intuition behind a drug like this. I've read that it affects circadian rhythms. Yet I'm confused as to why this substance has no apparent effect on sleep and other circadian based behaviors? Indeed why was there no concern about insomnia? (I'm two days in running 20mg/day sublingually, and have experienced no sides nor have I read about any in others' logs). And why would one think a substance that modulates circadian rhythms would be helpful for fat loss or body recompositioning? I've also read that it has a cosmetic effect and improves the skin. Was this predictable? Do we know why this occurs?
What they were answering
shrillthrill · 1 points
Kinda curious how scant research is for other AMPK activators on REV-ERBalpha. Would like to see comparative research (in many tissues) elucidating why SR9009 does it better than resveratrol, curcumin, etc. Those things also upregulate ABCA1.
u/MisterYouAreSoDumb
I would assume because SR9009 agonizes Rev-ErbA, and resveratrol/curcumin just up-regulates it. There certainly needs to be more research into the mechanisms.