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Comment · Tue, March 31, 2020 · Natrium Health & Nootropics Depot

Does Adamax upregulate Trkb to the same degree as Semax?

Original post in this thread

germaneman · 3 points

Same question as title. Wanting to know if it upregulates Trkb

What they were answering

germaneman · 3 points

I ran 50 mg 7,8 DHF for a month and I am experiencing a rebound for days now. Can’t tell if I’m just back to my normal self or if I’m slower and more depressed due to a rebound.

Anyone else experienced this or have ideas on how to get Trkb back online? That’s main reason I’m using Adamax rn

u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot

Berberine, crucumin, EGCG, and polygala.

http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=6;spage=983;epage=984;aulast=Habtemariam

Good examples are curcumin, resveratrol, (-)-epigallocatechin-3-gallate (EGCG), and berberine [Figure 1]. Under various experimental conditions, these compounds have been shown to increase the BDNF level under neurodegenerative experimental models both in vitro and in vivo. Since these compounds are active in modulation of gene expression and signal transduction pathways associated with cell growth and differentiation, their effect on BDNF production could be a result of multiple mechanisms.

Berberine Ameliorates MCAO Induced Cerebral Ischemia/Reperfusion Injury via Activation of the BDNF–TrkB–PI3K/Akt Signaling Pathway

Effect of Polygala tenuifolia Willd YZ-50 on the mRNA expression of brain-derived neurotrophic factor and its receptor TrkB in rats with chronic stress depression

Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons.

Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide.

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