Comment · Sat, August 8, 2015 · Ceretropic
Long-acting ghrelin mimetics (MK-677) negatively affect fear processing. (MK-677!)
Original post in this thread
aesthet · 18 points
Study:
[A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear, RM Meyer, Molecular Psychiatry \(2014\), 1284 – 1294](
http://www.nature.com/mp/journal/v19/n12/full/mp2013135a.html)
Here we demonstrate changes in endogenous ghrelin following stress and also use a low-dose, long-acting agonist to replicate the naturally occurring ghrelin state. We also provide clear evidence that acute and chronic ghrelin receptor manipulations have profoundly different effects. It is important to note that the changes in fear reported here occurred following small, but persistent, changes in ghrelin signaling, and all were in the absence of any locomotor effects.
We suggest that the utility of ghrelin in the stress response may be similar to glucocorticoids: under ‘normal’ conditions, there is an optimal level of the hormone, and too little, or too much hormonal signaling can lead to dysfunction in neuronal circuits. Repeated activation of ghrelin and glucocorticoid pathways together contributes to stress-induced ‘load’ on the body. In this regard, heightened ghrelin signaling may have both advantageous and undesirable consequences, but these must be ca…
What they were answering
Debonaire_Death · 2 points
NOW foods has an IGF-1+ product that turned me on to the extract in general. I have recently been trying out Pure IGF by Pure Solutions, which seems to be a broader-array extract not as geared to appetite (funny, considering its proud name claim to purity), but has seemed to be having an impact on my overall caloric intake and, interestingly, my ability to control cravings and impulses--you don't really feel it working, though. With the NOW brand, if I dose too early in my exercise, I can start getting hypoglycemia as I'm fixing my post-workout shake: intense! It reminds me of MK-677 in that respect. The days MK really kicked in, there were those "I need to eat something now" moments.
u/MisterYouAreSoDumb · Ceretropic
That NOW one is interesting. It is a sublingual spray made from deer antler velvet extract.