Comment · Sat, August 8, 2015 · Ceretropic
Long-acting ghrelin mimetics (MK-677) negatively affect fear processing. (MK-677!)
Original post in this thread
aesthet · 18 points
Study:
[A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear, RM Meyer, Molecular Psychiatry \(2014\), 1284 – 1294](
http://www.nature.com/mp/journal/v19/n12/full/mp2013135a.html)
Here we demonstrate changes in endogenous ghrelin following stress and also use a low-dose, long-acting agonist to replicate the naturally occurring ghrelin state. We also provide clear evidence that acute and chronic ghrelin receptor manipulations have profoundly different effects. It is important to note that the changes in fear reported here occurred following small, but persistent, changes in ghrelin signaling, and all were in the absence of any locomotor effects.
We suggest that the utility of ghrelin in the stress response may be similar to glucocorticoids: under ‘normal’ conditions, there is an optimal level of the hormone, and too little, or too much hormonal signaling can lead to dysfunction in neuronal circuits. Repeated activation of ghrelin and glucocorticoid pathways together contributes to stress-induced ‘load’ on the body. In this regard, heightened ghrelin signaling may have both advantageous and undesirable consequences, but these must be ca…
What they were answering
Debonaire_Death · 3 points
Well you can't argue with a man's feelings: I stand corrected!
On the subject of this thread, though, what do you think of Deer Antler Velvet Extract? I've been using it for awhile and it's worked great for helping me get more of an appetite and put on some weight, but I've been concerned about long-term consequences. Places online say to take a month break after, like, 7 months (maybe?, something like that), but these were vendors so they could just want me to use the maximum possible amount so they make more money.
u/MisterYouAreSoDumb · Ceretropic
I have been hearing a lot about deer antler velvet lately. It does not seem to have a ton of scientific data. However, there are some good anecdotes. Certain species seem to be better than others. It contains zinc, magnesium, calcium, amino acids, and prostaglandins. So I could see some people perhaps getting results from it.