Comment · Wed, July 29, 2015 · Ceretropic
"You do not need to take fat with fat soluble vitamins"
Original post in this thread
theskepticalidealist · 25 points
I wanted to have people comment on this thread but it's been archived and now you can't.
So, fact or fiction? Some people said fiction so wanted a discussion to make it clearer to people.
What they were answering
MezDez · 2 points
Selegiline has a low oral bioavailability, which increases to moderate when ingested together with a high-fat meal, the molecule being fat soluble.[21]
why would this be the case for selegiline?
u/MisterYouAreSoDumb · Ceretropic
Everything I am seeing shows that selegiline is rapidly absorbed in all parts of the GI tract from a fasting state. It is then quickly metabolized into desmethylselegiline, levoamphetamine and levomethamphetamine. It's not the absorption that is the issue. It's the rapid first pass metabolism. Fat solubility has nothing to do with it.