Memantine - getting an opposite effect than expected

A couple of months ago when I first received the Memantine I was dumb (so dumb), and took 10mg the next morning before learning about titrating. The next day I took 5mg and also took my first Xyrtec of the season that evening. I had a horrible night sleep and was very sick the next day. Though it must be a drug interaction and called the pharmacist but the said no way. It was a couple of weeks then before I took another Xyrtec and then tried Memantine again with proper titrating.

This time I've titrated up to 10mg per day as recommended by MYASD. 4 days now at 10mg per and my irritability has become unmanageable. Depression has also taken root. Not sure if it's just not playing well with my other supps, or if it's just me. Today is my first day off of Memantine so I'll stay off for the next couple of weeks and reevaluate. My other supps include ALCAR, Noopept, Creatine, multivitamin, fish oil, D3, Tianeptine, AMP citrate occasionally, Phenylpiracetam occasionally, Gabapentin 300mg at night (actute chronic back pain), Xyrtec each morning for allergies. I suspect Xyrtec may be the culprit, but perhaps Memantine is just not right for me.

So what do you think? Was the first incide…