Comment · Wed, April 22, 2015 · Ceretropic
Has anyone tried TLR's J147?
Original post in this thread
sayitaintsoap · 2 points
I recall this vendor having tremendous difficulty with the synthesis of this compound as they continuously pushed the release date farther and farther back but it eventually was put up for purchase very recently without much commotion. Has anyone taken it? It sounds very promising for the treatment of Alzheimer's disease from what I have read.
What they were answering
NotHyplon · 1 points
Yep. I figured since everyone and their dog seems to want to make a nootropic movie\ tv show\ newspaper post i would start a treatment for NCIS:Arizona.
It will be like Cop's with science, exciting leet haxing scenes as lost packages are found, shady deals using a catapult to fire noots over the mexican border to supply your supplier down there. The guy at ND having an argument with his partners and being told to hand in his badge and HPLC machine for wanting to sell rarer chemicals.
Then there is the suave European running a one man crusade against the media and phenibut. This band of misfits eventually discover that TLR are planning to poison the nootropics scene with MPTP as "ADicOXCUREALLtotesREAL"
It reaches a crescendo when the team track down team TLR who pull off Paycoin level of gymnastics to get away, a car chase ensues and just when all is lost Isochroma smashes a state correctional facilities bus into the TLR getaway mobile and saves the day!
When the police arrive there is no sign of him but because the chase took place in Georgia (those tax breaks) the NCIS: Arizona crew are in serious judicial trouble whilst the European gets deported
u/MisterYouAreSoDumb · Ceretropic
Sounds fantastic!
Hey, guess what? We just found out that TLR's 7,8-DHF is not good. Unfortunately that also means our 7,8-DHF that we have been waiting to put up is also not correct. We are testing THT's against the results in a day or so. However, I suspect that it might not be actual 7,8-DHF either.
Take a look at the sample we got in compared to TLR's sample.
They are the same. They have the same peaks, and match up perfectly.
But now take a look at it compared to Sigma Aldrich's reference.
~~See how those distinctive peaks are missing at 2800-3000? That is where the ketone should be. TLR's sample and our sample are missing the ketone group. Then look at how the ghosting is higher at 3100. That means there is an extra hydroxyl group taking the place of where the ketone should be. Because of that hydroxyl in place of the ketone, the extra electron picks up another hydrogen. So that is why the fingerprint section at 1600 and below is so off. The ketone would be a double bonded carbon to the oxygen. However, the hydroxyl is a single bonded carbon, which then picks up an extra hydrogen.~~
Basically someone dun fucked up the synthesis, and has been selling this Trihydroxyphenylfuck to multiple vendors. Anyone that has used TLR's 7,8-DHF has actually not been taking a flavone at all, but some frankenstein molecule. I am going to run THT's spectrum as well, and see how it compares. I would not be surprised if they were phenylfucking people too. I might make a post about this. I made nice little graphics and everything! I also have to yell at China again...
EDIT: Now we are arguing about ketones and alkenes. The spectrum might be showing a difference in carbon bonded hydrogens, rather than oxygens. The ketone should be at 1700. Either Sigma's reference is wrong, or our sample is wrong. Colin will settle it with an NMR.