Comment · Thu, January 15, 2015 · Ceretropic
Bromantane+l-deprenyl+Tianeptine for ADD?
Original post in this thread
redan-yadayada · 6 points
Has anyone tried this combination or is looking to? I'm interested in any experience reports.
I'm thinking along the lines of using Bromantane for the TH mRNA upregulation by almost 200%, while using selegiline to keep DA levels up so DAT don't decrease the amount of DA available in synapses, while using Tianeptine to increase the effectiveness of D2/D3 receptor binding and increase sensitization.
What else have I not covered in this stack for ADD so as to counter homeostasis and tolerance?
Thanks.
What they were answering
redan-yadayada · 1 points
I compiled all the interesting papers on how Bromantane works here:
http://www.reddit.com/r/Nootropics/comments/2pmvf2/ladastenbromantane_induces_profound_effects_on/
It has some pretty strong effects on tyrosine hydroxylase gene expression along with inhibitory properties on GABA-T activity. Some people don't like the mellow serotonin along with increased GABA neurotransmitter level feeling, of ahh.
Personally I like the effects the day after, not the immediate effects on serotonin and dopamine reuptake in the PFC area (the TH mRNA upregulation).
We investigated the effects of a single peroral ladasten administration on the level of tyrosine hydroxylase (TH) mRNA and protein and L-DOPA and dopamine content in VTA, N. accumbens, hypothalamus, striatum and hippocampus. Ladasten administration differentially modulated the TH mRNA content in VTA, hypothalamus, striatum and hippocampus. Already 30 min after ladasten administration the level of TH mRNA was significantly increased in the VTA and reached its maximum (220%) 1 h later.
and
It is therefore assumed that psychostimulant actions lead to a short- or long-lasting depletion of DA stores that requires a reinforcement of DA synthesis to restore dopaminergic functions (Shishido et al., 1997). In the present study we could show that administration of the mild psychostimulant ladasten affects dopamine biosynthesis…
u/MisterYouAreSoDumb · Ceretropic
It definitely has some unique effects. So you prefer the effects a day after ceasing use?