Comment · Fri, December 19, 2014 · Ceretropic
Semax Summary
Original post in this thread
RogerZamboni · 15 points
OKHi, I'm not as experienced in scientific research as others, but here's a summary of what I've found. I was trying to find a post on what to expect out of semax... and didn't find one so I tried to find some papers on it.
SYNTHETIC ACTH ANALOGUE SEMAX DISPLAYS NOOTROPIC-LIKE ACTIVITY IN HUMANS
http://brain.bio.msu.ru/papers/Kaplan_Kochetova_Nezavibathko_Rjasina_Ashmarin_1999_NeurosciResCommun_NootropicSemaxInHumans.pdf
Abstract: Nootropic properties of ACTH4-10 analogue, Semax, were demonstrated in experiments
with human volunteers. The antihypoxic effect of Semax was shown by EEG analysis after shortterm
hyperventilation. Semax induced changes in the EEG similar to those seen after
administration of typical nootropic drugs. Particularly important was the long-term (20-24 h)
beneficial action of Semax on the work efficiency of operators after intranasal administration of
0.25- 1.0 mg of the peptide (about 4.0 - 16.0 /xg/kg body weight).
Summary
Method
16 operators of a power plant were asked to memorize 160 blocks of random number images. Then, they were presented with 40 test numbers and asked to press a space bar if they were the same as of the 160 number images. Half…
What they were answering
cobue · 6 points
"However, prolonged administration (7 days) reduced levels of dopamine and serotonin. "
Most interesting part. I´m taking n-acetyl-semax from ceretropic since over 2 weeks, this is a little worrying.
u/MisterYouAreSoDumb · Ceretropic
Taking the quote out of context changes things...
> Chronic daily administration of Semax (600 μg/kg per day) for 7 days tended to reduce the levels of dopamine and serotonin significantly **in the
hypothalamus.** These findings suggest the accelerated turnover of serotonin, reflecting an increase in the functional activity of this mediatory system [87]. Pretreatment with Semax potentiated the effects of D-amphetamine on the dopaminergic system of the striatum and on the locomotor activity of rats. The authors of that work suggest that Semax increases dopamine transmission in the striatum [88].
It only noted lowered dopamine and serotonin levels in the hypothalamus. The hypothalamus is responsible for the synthesis and creation of various hormones, including dopamine, serotonin, oxytocin, prolactin, etc. We are not talking about an overall depletion of serotonin in the entire brain, or frontal cortex.