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Comment · Fri, December 19, 2014 · Ceretropic

Speculation: tianeptine + SSRI??

Original post in this thread

Bomb_Jack · 1 points

Hi all.

I was just wondering if it could be possible to take an ssri with tianeptine in order to cancel its serotonin uptake enhancing effect and so exploit its other benefits on the other single receptors (a bit like it's done with buprenorphine + samidorphan), or you would cause just an hazardous mess??

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Ceretropic

Tianeptine can be combined with an SSRI for treatment-resistant depression.

Tianeptine combination for partial or non-response to selective serotonin re-uptake inhibitor monotherapy.

A combination strategy with tianeptine may be an effective and well-tolerated tool for patients who have failed to adequately respond to SSRI monotherapy.

I would not worry too much about the mild, if any, SSRE actions.

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